Parental preferences for childhood vaccination regimens with diphtheria,tetanus,and acellular pertussis;hepatitis B;inactivated poliovirus;and Haemophilus influenzae type b containing vaccines:a discrete choice experiment in selected cities
Objective To explore parental preferences for childhood vaccination regimens with diphtheria,tetanus,and acellular pertussis(DTaP);hepatitis B(HepB);inactivated poliovirus(IPV);and Haemophilus influenzae type b(Hib)containing vaccines.Methods We recruited a convenience sample of parents of 0-6-year-old children from 6 vaccination clinics in 3 cities of China and conducted a questionnaire-based discrete choice experiment.We used a mixed logit model to estimate parameter values of preferences for different vaccination regimens with DTaP,HepB,IPV,and/or Hib containing vaccines and probabilities of choices.Results A total of 220 subjects were recruited into the study.Mixed logit regression showed that fewest scheduled doses(β=3.40,95％CI:3.03-3.77)and lowest incidence of common vaccine reactions(β=2.56,95％CI:2.18-2.94)were the most important preferences.There was heterogeneity of preferences by characteristics of the subjects.A 5-dose schedule using imported vaccines with an incidence of common reaction of 1/50 costing parents 800 yuan had a probability of choice of 99.83％.Conclusions Parental preferences for combination childhood vaccine regimens were most influenced by the number of doses required and the safety of the vaccine.More safe combination vaccines should be developed and used for children.
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