首页|济南市2017-2021年急性脑炎脑膜炎症候群监测病例病原谱分析

济南市2017-2021年急性脑炎脑膜炎症候群监测病例病原谱分析

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目的 了解济南市急性脑炎脑膜炎症候群(Acute meningitis and encephalitis syndrome,AMES)监测病例病原谱构成.方法 2017-2021年在济南市7家医院开展AMES病例监测,采集血清和/或脑脊液标本,检测乙型脑炎病毒(Japanese encephalitis virus,JEV)、肠道病毒(Enterovirus,EV)、流行性腮腺炎病毒(Mumps virus,MuV)和单纯疱疹病毒(Herpes simplex virus,HSV)IgM 抗体以及脑膜炎奈瑟菌(Neisseria meningitides,Nm)、肺炎链球菌(Streptococcus pneumoniae,Spn)和b型流感嗜血杆菌(Haemophilus influenza type b,Hib)抗原,分析IgM抗体和抗原阳性率.结果 AMES 病例 JEV、EV、MuV、HSV IgM 抗体阳性率分别为 3.15％(82/2 604)、13.62％(298/2 188)、10.92％(239/2 188)、4.94％(108/2 188),其中最高年龄别阳性率分别为 7.61％(≥40 岁)、30.09％(5-9 岁)、16.52％(5-9 岁)、7.16％(≥40 岁);Nm、Spn、Hib 抗原阳性率分别为 2.07％(50/2 420)、1.03％(25/2 420)、0.08％(2/2 420),其中最高年龄别阳性率分别为4.65％(25-29岁)、2.56％(20-24岁)、0.17％(≥40岁).在Nm抗原阳性病例中B群病例占44％(22/50).结论 济南市2017-2021年AMES病例优势病原为EV、MuV、HSV和JEV.建议加强儿童EV和MuV免疫预防,开展≥40岁人群乙脑疫苗接种,加快B群Nm疫苗研发和应用.
Pathogen spectrum of acute meningitis and encephalitis syndrome cases in Jinan city,2017-2021
Objective To determine the spectrum of pathogens of acute meningitis and encephalitis syndrome(AMES)cases in Jinan city.Methods We collected serum and/or cerebrospinal fluid samples of AMES cases in seven sentinel hospitals of Jinan during 2017-2021.We tested for Japanese encephalitis virus(JEV),enterovirus(EV),mumps virus(MuV),and herpes simplex virus(HSV)IgM antibodies and Neisseria meningitides(Nm),Streptococcus pneumonia(Spn),and Haemophilus influenza type b(Hib)antigens to determine positivity rates.Results Prevalences of JEV,EV,MuV,and HSV IgM antibodies were 3.15％(82/2 604),13.62％(298/2 188),10.92％(239/2 188),and 4.94％(108/2 188),respectively,with the highest age-specific positivity rates being 7.61％in ≥40-year-olds,30.09％in 5-9-year-olds,16.52％in 5-9-year-olds,and 7.16％in ≥40-year-olds.Positivity rates of Nm,Spn,and Hib antigens were 2.07％(50/2 420),1.03％(25/2 420),and 0.08％(2/2 420),with the highest age-specific positivity rates being 4.65％in 25-29-year-olds,2.56％in 20-24-year-olds,and 0.17％in ≥40-year-olds.Group B Nm cases accounted for 44％(22/50)of Nm antigen positive cases.Conclusions The dominant AMES pathogens in Jinan during 2017-2021 were EV,MuV,HSV,and JEV.We should strengthen childhood EV and MuV vaccination,conduct JEV vaccination of ≥40-year-olds,and accelerate group B Nm vaccine research,development,and use.

Acute meningitis and encephalitis syndromeVirusBacteriaPathogen spectrum

武晶晶、刘子薇、谭丽、杨风华、孙红云

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济南市疾病预防控制中心,山东济南 250021

平阴县疾病预防控制中心,山东济南 250400

急性脑炎脑膜炎症候群 病毒 细菌 病原谱

2024

10.19914/j.CJVI.2024026

中国疫苗和免疫
中国疾病预防控制中心

中国疫苗和免疫

CSTPCD北大核心
影响因子：2.311
ISSN：1006-916X
年,卷(期)：2024.30(2)
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