目的 了解西藏自治区2020年1-69岁人群乙型病毒性肝炎(乙肝)血清流行率.方法 采用多阶段整群随机抽样法选取西藏自治区5个疾病监测点1-69岁人群采集血清标本.使用酶联免疫吸附试验检测乙肝表面抗原(Hepatitis B surface antigen,HBsAg)、表面抗体(Hepatitis B surface antibody,HBsAb)和核心抗体(Hepatitis B core antibody,HBcAb),使用微粒子酶联免疫法对HBsAg阳性标本检测乙肝e抗原(Hepatitis B e antigen,HBeAg)和e抗体(Hepatitis B e antibody,HBeAb),分析乙肝病毒(Hepatitis B virus,HBV)标志物阳性率和组合模式.结果 在4 912例调查对象中,HBsAg、HBsAb、HBcAb 阳性率分别为 9.20％、37.11％、32.76％(标化率:8.65％、37.30％、30.35％).1-4岁、5-14岁、15-29 岁、30-69 岁 HBsAg 阳性率分别为 2.23％、2.85％、6.87％、12.46％,HBsAb 阳性率分别为52.79％、32.67％、37.71％、36.03％,HBcAb 阳性率分别为4.19％、6.42％、21.09％、46.95％.共检出 13 种 HBV 标志物组合模式,其中五项标志物阴性、HBsAb单项阳性、HBsAg+HBcAb+HBeAb阳性、HBsAg+HBcAb+HBeAg阳性分别占总调查对象的43.79％、22.39％、6.15％、1.65％.结论 2020年西藏自治区1-69岁人群特别是儿童HBsAg阳性率和HBV感染率显著下降,存在一定比例易感人群.仍需重点加强新生儿乙肝疫苗及时和全程接种工作.
A seroepidemiological survey of hepatitis B markers in people aged 1-69 years in Xizang Autonomous Region in 2020
Objective To explore seroprevalence of hepatitis B markers among people 1-69 years of age in Xizang Autonomous Region in 2020.Methods We selected 1-69-year-olds from five disease surveillance points in Xizang using a multi-stage cluster random sampling method.We collected serum samples to test for hepatitis B surface antigen(HBsAg),surface antibody(HBsAb),and core antibody(HBcAb)using enzyme-linked immunosorbent assay,and hepatitis B e antigen(HBeAg)and e antibody(HBeAb)of HBsAg-positive samples using microparticle immunosorbent assay.We calculated positivity rates and patterns of the hepatitis B virus(HBV)markers.Results Among the 4 912 subjects,HBsAg,HBsAb,and HBcAb positivity rates were 9.20％,37.11％,and 32.76％(adjusted:8.65％,37.30％,and 30.35％),respectively.In 1-4-,5-14-,15-29-,and 30-69-year-olds,HBsAg positive rates were 2.23％,2.85％,6.87％,and 12.46％;HBsAb positive rates were 52.79％,32.67％,37.71％,and 36.03％;HBcAb positive rates were 4.19％,6.42％,21.09％,and 46.95％.Thirteen HBV marker combinations were detected.Subjects who were negative to all five markers,positive to only HBsAb,positive to HBsAg+HBcAb+HBeAb,and positive to HBsAg+HBcAb+HBeAg accounted for 43.79％,22.39％,6.15％,and 1.65％of subjects.Conclusions HBsAg seroprevalence,which indicates HBV infection,declined significantly among people aged 1-69 years,especially children,in Xizang in 2020,but a susceptible population remains.We still need to strengthen timely and full-series hepatitis B vaccination of newborns.
Viral hepatitis BHepatitis B virusSerum markerSeroprevalence
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