Adverse reactions following co-administration of 13-valent pneumococcal polysaccharide conjugate vaccine and rotavirus vaccine among children under 3 years old in Hubei province,2018-2021
Objective To evaluate adverse reactions following co-administration of 13-valent pneumococcal conjugate vaccine(PCV13)and rotavirus vaccine(RV)in children under 3 years of age.Methods We obtained data on PCV13 and RV doses administered and reported adverse reactions among children under 3 years of age in Hubei province during 2018-2021 from the Hubei and China immunization information management systems.We used Poisson regression models to calculate incidence rates(95％CI)of reported adverse reactions following simultaneous and standalone vaccination with PCV13 and RV,adjusted by age,gender,and quarter of the year.Results Incidence rates(95％CI)per 100 000 doses of reported adverse reactions following simultaneous administration of PCV13 and RV,standalone PCV13,and standalone RV vaccination were 61.64(44.28-85.79),57.13(51.49-63.37),and 23.88(21.66-26.33),with 57.82(40.94-81.66),52.76(47.36-58.78),and 21.17(19.08-23.48)being common reactions and 2.69(0.66-10.97),3.65(2.42-5.49),and 1.70(1.18-2.45)being rare reactions.Conclusions The reported incidences of adverse reactions among children under 3 years old following simultaneous or standalone PCV13 and RV vaccination were within the expected range.Co-administration of the two vaccines did not increase risk of adverse reactions.
NETL
NSTL
万方数据
