2018-2021年湖北省＜3岁儿童13价肺炎球菌多糖结合疫苗与轮状病毒疫苗联合接种不良反应评价
Adverse reactions following co-administration of 13-valent pneumococcal polysaccharide conjugate vaccine and rotavirus vaccine among children under 3 years old in Hubei province,2018-2021
孙芯蕊 1杨帆 1王齐 1王雷 2魏晟3
作者信息
- 1. 华中科技大学同济医学院公共卫生学院流行病与卫生统计学系,湖北武汉 430030
- 2. 湖北省疾病预防控制中心,湖北武汉 430079
- 3. 华中科技大学同济医学院公共卫生学院流行病与卫生统计学系,湖北武汉 430030;南方科技大学公共卫生及应急管理学院,广东深圳 518055
- 折叠
摘要
目的 评价＜3岁儿童13价肺炎球菌多糖结合疫苗(Pneumococcal conjugate vaccine,PCV13)与轮状病毒疫苗(Rotavirus vaccine,RV)联合接种的不良反应.方法 通过湖北省和中国免疫规划信息管理系统分别收集湖北省2018-2021年＜3岁儿童PCV13和RV接种剂次数和不良反应报告数据.采用Poisson回归模型计算经年龄、性别和季度调整的PCV13和RV联合/单独接种不良反应报告发生率及其95％CI.结果 PCV13与RV联合接种、PCV13单独接种、RV单独接种不良反应报告发生率及其95％CI(/10万剂)分别为61.64(44.28-85.79)、57.13(51.49-63.37)、23.88(21.66-26.33),其中一般反应分别为 57.82(40.94-81.66)、52.76(47.36-58.78)、21.17(19.08-23.48),异常反应分别为 2.69(0.66-10.97)、3.65(2.42-5.49)、1.70(1.18-2.45).结论 ＜3 岁儿童 PCV13 和 RV联合或单独接种不良反应报告发生率均在预期范围内,联合接种未增加不良反应发生风险.
Abstract
Objective To evaluate adverse reactions following co-administration of 13-valent pneumococcal conjugate vaccine(PCV13)and rotavirus vaccine(RV)in children under 3 years of age.Methods We obtained data on PCV13 and RV doses administered and reported adverse reactions among children under 3 years of age in Hubei province during 2018-2021 from the Hubei and China immunization information management systems.We used Poisson regression models to calculate incidence rates(95％CI)of reported adverse reactions following simultaneous and standalone vaccination with PCV13 and RV,adjusted by age,gender,and quarter of the year.Results Incidence rates(95％CI)per 100 000 doses of reported adverse reactions following simultaneous administration of PCV13 and RV,standalone PCV13,and standalone RV vaccination were 61.64(44.28-85.79),57.13(51.49-63.37),and 23.88(21.66-26.33),with 57.82(40.94-81.66),52.76(47.36-58.78),and 21.17(19.08-23.48)being common reactions and 2.69(0.66-10.97),3.65(2.42-5.49),and 1.70(1.18-2.45)being rare reactions.Conclusions The reported incidences of adverse reactions among children under 3 years old following simultaneous or standalone PCV13 and RV vaccination were within the expected range.Co-administration of the two vaccines did not increase risk of adverse reactions.
关键词
13价肺炎球菌多糖结合疫苗/轮状病毒疫苗/联合接种/不良反应Key words
13-valent pneumococcal polysaccharide conjugate vaccine/Rotavirus vaccine/Co-vaccination/Adverse reaction引用本文复制引用
出版年
2024
NETL
NSTL
万方数据