摘要
目的 分析中国健康人群破伤风抗体水平.方法 通过中英文文献数据库检索2000-2023年发表的中国健康人群破伤风抗体水平相关研究文献,对纳入文献进行Meta分析,计算破伤风IgG抗体阳性(≥0.01IU/mL)率和保护(≥0.1IU/mL)率的合并效应值.结果 共纳入34篇文献,覆盖中国15个省份,研究总样本量为30 741例.Meta分析显示,全健康人群破伤风抗体阳性率、保护率的合并效应值分别为80.81％(95％CI:72.54％-87.90％)、55.15％(95％CI:44.32％-65.74％).＜1 岁、1-2 岁、3-4 岁、5-6 岁、7-14 岁、15-19 岁、20-39 岁、≥40 岁阳性率合并效应值分别为 98.86％、98.67％、98.15％、95.86％、91.22％、86.08％、82.96％、48.73％(x2=38.64,P＜0.001),保护率合并效应值分别为 89.65％、92.60％、90.20％、87.58％、71.54％、43.18％、23.68％、12.56％(X2=259.03,P＜0.001).结论 中国健康人群破伤风抗体水平总体较高且随年龄增长呈下降趋势;需完善人群破伤风免疫策略.
Abstract
Objective To analyze tetanus antibody levels in healthy populations in China.Methods We retrieved research studies on tetanus antibody levels in healthy Chinese populations published from 2000 to 2023 from Chinese and English language databases.We conducted meta-analyses of included studies to estimate pooled tetanus IgG antibody positive(≥0.01IU/mL)rates and protective(≥0.1IU/mL)rates.Results A total of 34 studies were included,involving 15 provinces of China,with a total sample size of 30 741 subjects.Meta-analysis showed that pooled positivity and protection rates in healthy Chinese populations were 80.81％(95％CI:72.54％-87.90％)and 55.15％(95％CI:44.32％-65.74％),respectively.Pooled positivity rates for＜1-,1-2-,3-4-,5-6-,7-14-,15-19-,20-39-,and ≥40-year-olds were 98.86％;98.67％,98.15％,95.86％,91.22％,86.08％,82.96％,and 48.73％(x2=38.64,P＜0.001),with pooled protection rates being 89.65％,92.60％,90.20％,87.58％,71.54％,43.18％,23.68％,and 12.56％(x2=259.03,P＜0.001).Conclusions The tetanus antibody level was generally high in healthy populations in China and decreased with increasing age.We suggest improving tetanus immunization strategies for Chinese populations.
NETL
NSTL
万方数据