Use of an indirect cohort design for evaluation of vaccine effectiveness
Post-marketing vaccine effectiveness(VE)evaluation is an epidemiological assessment of vaccinations to prevent and control diseases in the real world.The indirect cohort design(ICD)is a study design that uses individual-level vaccination history data and infecting pathogen serotypes of patients with vaccine-targeted diseases to calculate VE.An ICD can effectively reduce sample size,lower study cost,and retain high credibility.In this article,we review principles,post-marketing VE evaluations,and advantages and limitations of ICD,aiming to help researchers better understand and conduct ICD VE evaluations.
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