Adverse reactions following vaccination with varicella attenuated live vaccine among healthy children aged 1-12 years:an observational study in areas of Anhui province
Objective To evaluate incidences of adverse reactions following vaccination with varicella attenuated live vaccine(VarV)among age-eligible children.Methods We recruited healthy children aged 1-12 years from vaccination clinics in five prefectures of Anhui province and followed them for adverse reactions 0-30 days after one-dose of VarV to determine incidences.Results A total of 9 169 subjects were included in the study.The overall incidence of adverse reactions after VarV vaccination was 1.09％(100 cases),with 0.69％(63 cases)local reactions and 0.46％(42 cases)systemic reactions;respective highest incidences were 0.40％for injection-site pain and 0.26％for fever.No level 3/level 4,serious adverse reactions or adverse events of special concern were reported.Incidences of adverse reactions were 1.47％(64/4 347)for 1-3-year-olds and 0.75％(36/4 822)for 4-12 year-olds(x2=11.16,P＜0.001).Conclusion Adverse reactions were mild after a single dose of VarV vaccination among 1-12-year-old healthy children,and incidences of adverse reactions were less than expected.
Varicella attenuated live vaccineVaccinationAdverse reaction
万方数据
维普
