目的 了解湖南省2020年1-69岁人群乙型肝炎(乙肝)病毒标志物血清流行率.方法 采用分层多阶段整群随机抽样方法选取湖南省4个县区1-69岁常住人口开展问卷调查和采集血清标本,检测血清乙肝表面抗原(Hepatitis B surface antigen,HBsAg)、表面抗体(Hepatitis B surface antibody,HBsAb)、核心抗体(Hepatitis B core antibody,HBcAb)、e 抗原(Hepatitis B e antigen,HBeAg)和 e 抗体(Hepatitis B e antibody,HBeAb),分析阳性率.结果 在 3 111 名调查对象中,HBsAg、HBsAb、HBcAb、HBeAg、HBeAb 阳性率分别为 3.05％、51.11％、26.87％、0.23％、7.39％.1-4 岁、5-14 岁、15-29 岁、30-69 岁人群 HBsAg 阳性率分别为 0.35％、0.00％、0.46％、5.24％,HBsAb 阳性率分别为 75.53％、56.65％、42.92％、48.85％,HBcAb 阳性率分别为 8.16％、4.36％、12.33％、41.07％,HBeAg 阳性率分别为 0.00％、0.00％、0.30％、0.29％,HBeAb 阳性率分别为 2.13％、0.69％、2.44％、11.81％.结论 湖南省儿童HBV感染得到了有效控制而成人HBV感染相对较高.需巩固儿童乙肝疫苗常规免疫和乙肝母婴传播阻断措施,探索成人乙肝防控策略.
Hepatitis B seroprevalence in people 1-69 years of age:a cross-sectional survey in Hunan province in 2020
Objective To determine seroprevalence of hepatitis B virus(HBV)markers among people aged 1-69 years in Hunan province in 2020.Methods We used a stratified multi-stage cluster random sampling method to select 1-69-year-old residents from nine communities of four counties/districts in Hunan for a questionnaire-based survey.We collected serum samples to test for hepatitis B surface antigen(HBsAg),surface antibody(HBsAb),core antibody(HBcAb),e antigen(HBeAg),and e antibody(HBeAb)and calculate seropositivity rates.Results Among 3 111 subjects,positivity rates of HBsAg,HBsAb,HBcAb,HBeAg,and HBeAb were 3.05％,51.11％,26.87％,0.23％,and 7.39％,respectively.Among 1-4-,5-14-,15-29-,and 30-69-year-olds,positivity rates for HBsAg were 0.35％,0.00％,0.46％,and 5.24％;for HBsAb were 75.53％,56.65％,42.92％,and 48.85％;for HBcAb were 8.16％,4.36％,12.33％,and 41.07％;for HBeAg were 0.00％,0.00％,0.30％,and 0.29％;and for HBeAb were 2.13％,0.69％,2.44％,and 11.81％.Conclusions HBV infection is effectively controlled in children but remains at a high level in adults in Hunan.We should consolidate childhood routine hepatitis B vaccination and interruption of mother-to-infant transmission of HBV,and explore strategies for prevention and control of adult hepatitis B.
Hepatitis BHepatitis B virusHepatitis B virus markerSeroprevalence
万方数据
维普
