Varicella-zoster virus antibody levels among 8-20-year-olds in Deqing county in 2022
Objective To determine seroprevalence of varicella zoster virus(VZV)antibody among primary and middle school students in Deqing county.Methods We used a stratified cluster random sampling method to select 8-20-year-old students from five primary and middle schools in Deqing and collect serum samples.We tested sera for VZV immunoglobulin G(IgG)antibody using enzyme-linked immunosorbent assay and calculated positivity rates and geometric mean concentration(GMC).Results The overall positivity rate and GMC of VZV IgG antibody among subjects were 55.70％(1 100/1 975)and 98.79 mIU/mL.Multivariate logistic regression showed that the positive rate decreased with increasing age(OR=0.96,95％CI:0.93-0.99);was lower in males than females(OR=0.71,95％CI:0.59-0.85);was higher among subjects with varicella history than among subjects without varicella history(OR=9.10,95％CI:4.53-18.31);and was higher among subjects who received two doses of varicella vaccine(OR=1.94,95％CI:1.31-2.86)and with no significant difference among subjects who received one dose of vaccine(OR=0.75,95％CI:0.49-1.10),compared with subjects who received no varicella vaccine doses.Conclusions Seroprevalence of VZV antibody was generally low among primary and middle school students in Deqing.We recommend increasing two-dose varicella vaccination coverage in age-eligible children.
VaricellaVaricella-zoster virusAntibody levelPrimary and middle school student
万方数据
维普
