A meta analysis on correlation between polymorphisms of methylenetetrahydrofolate reductase and unexplained recurrent spontaneous abortion
Objective:To analyze correlation between polymorphisms of the 5,10 methylenetetrahydrofolate reductase (MTHFR) C667T and unexplained recurrent spontaneous abortion (URSA).Methods:Literatures of correlation between polymorphisms of MTHFR C667T and URSA were comprehensively searched in database such as PubMed,CNKI,Wanfang、CBM and (VIP).Literature screening was conducted according to the included criteria,literatures quality was evaluated,and the RevMan 5.3 software was used for meta-analysis.Results:A total of 31 literatures were included,and 3706 subjects were in URSA group,and 3937 subjects were in healthy control group.The results showed that the polymorphism of MTHFR C677T was correlated with URSA (T/C:OR=1.41,95％CI 1.23-1.6,P＜0.05;CT/CC:OR=1.23,95％CI 1.03-1.47,P＜0.05;(TT+CT)/CC:OR=1.45,95％CI 1.21-1.74,P＜0.05;TT/CC:OR=1.98,95％CI 1.51-2.59,P＜0.05).There was significant difference between URSA group and healthy control group (P＜0.05);The risk of URSA of domestic women with genotype TT was 3.56 times higher than that of domestic women with genotype CC when subgroup analysis was conducted.Genotype TT and allele T genetic were the risk factors of URSA (TT/CC:OR=3.56,95％CI 2.71-4.69,P＜0.05;T/C:OR=1.88,95％CI 1.66-2.13,P＜ 0.05;CT/CC:OR=1.67,95％CI 1.36-2.04,P＜0.05;(TT+-CT)/CC:OR=2.07,95％CI 1.71-2.50,P＜0.05),and there was significant different between URSA group and healthy control group (P＜0.05),but there was no sig-nificant different between URSA group and healthy control group for foreign women,which including other Asian women (P＞0.05).Conclusion:The gene polymorphism of MTHFR C667T is associated with URSA.And gene polymorphism of MTHFR C667T is the high risk factor of URSA for Chinese women,but there is no any correlation with foreign women including other Asian women.
NETL
NSTL
万方数据
维普
