Analysis of the high-risk factors and the preventive strategy of the uterine myomas recurrence with in 1 year after surgery
Objective:To explore the high-risk factors of postoperative recurrence of the uterine myoma,and to put for-ward the preventive measures.Methods:The clinical data of 200 patients with uterine myomas who had undergone surgical treatment in the hospital from January 2020 to March 2022 were analyzed retrospectively.According to wheth-er the patients with recurrence of the uterine myomas or not in 1 year of follow-up after surgery,these patients were divided in group A(patients with the recurrence of the uterine myomas)and group B(patients without the recurrence of the uterine myomas).The high-risk factors of the postoperative recurrence of the uterine myomas were analyzed by un-ivariate and multivariate Logistic regression.Results:The recurrence rate of uterine myomas of the patients within 1-year after surgery was 15.0％.There were significant differences in the body mass index,the diameter and number of uterine myomas,and the levels of estradiol(E2),follicle estrogen(FSH),luteinizing hormone(LH),carcinoembryonic antigen-125(CA125)and connective tissue growth factor(CTGF)of the patients between the two groups(all P＜0.05).Multivariate logistic regression analysis showed that the number of uterine myoma＞2,the high levels of FSH,LH,CA125 and CTGF of the patients in 1 year after surgery were the independent risk factors of their uterine myoma re-currence(P＜0.05),and the high level of E2 of the patients in 1 year after surgery was a protective factor of their uter-ine myoma recurrence(P＜0.05).The area under the curve(AUC)of the CA125 and CTGF levels of the patients in 1 year after surgery for predicting the recurrence of their uterine myoma in 1 year after surgery was 0.726 and 0.921.Conclusion:The high-risk factors of the postoperative uterine myoma recurrence of the patients include the multiple u-terine myoma,the abnormal sex hormone indexes levels and the high expressions of serum CA125 and CTGF,and which should be strengthen monitoring and the targeted intervention should be conducted to reduce the risk of the post-operative recurrence of the uterine myomas.
Uterine myomas surgeryRecurrence in 1 year after surgeryHigh-risk factorPreventive strategy
万方数据
维普
