Analysis of the changes of coagulation function and hemodynamics,and the maternal-neonatal outcomes of women with in-trahepatic cholestasis of pregnancy complicated with hypertensive disorder complicating pregnancy
Objective:To investigate the changes of coagulation function and hemodynamics,and the maternal-neonatal outcomes of pregnant women with intrahepatic cholestasis of pregnancy(ICP)complicated with hypertensive disorder complicating pregnancy(HDP).Methods:The clinical data of 60 pregnant women with ICP in group A,60 pregnant women with ICP complicated with HDP in group B and 60 healthy pregnant women in group C from June 2019 to June 2023 were collected retrospectively.The changes of coagulation function and hemodynamics of the women in the three groups were analyzed.The maternal-neonatal outcomes of the women in the three groups were counted.Results:The serum prothrombin time(12.19±1.39s,11.18±1.05s and 10.62±1.22s),the thrombin time(16.15±0.72s,15.24± 0.66s and 13.12±0.62s),and the activated partial thromboplastin time(26.37±4.18s,25.06±3.27s and 23.41±3.05 s)of the women in group C,in group A and in group B had decreased gradually.The fibrinogen level(4.15±0.45 g/L,4.58±0.52 g/L,4.98±0.61 g/L),the values of umbilical artery resistance index,pulsatility index and the ratio of the peak systolic velocity to the end diastolic velocity of the women in group C,in group A and in group B had increased gradually.The delivery gestational weeks(39.3±1.6 weeks,38.4±1.7 weeks and 38.0±1.4 weeks)of the women in group C,in group A and in group B had decreased gradually.The incidences of cesarean section and amniotic fluid con-tamination above grade Ⅱ of the women in group C,in group A and in group B had increased gradually.The incidences of the preterm birth(1.7％,15.0％and 18.3％),the low birth weight(0,6.7％and 10.0％)and the neonatal asphyxia(0,10.0％and 13.3％)of the women in group C,in group A and in group B had increased gradually(all P＜0.05).There was no significant difference in the incidence of intrauterine fetal death of the women among the three groups(P＞0.05).Conclusion:The coagulation function and hemodynamic indicators of the pregnant women with ICP complicated with HDP have changed significantly,which can influence the maternal-neonatal outcomes.The close mo-nitoring the relevant indicators is of great significance for improving the maternal-neonatal outcomes.
Intrahepatic cholestasis of pregnancyHypertensive disorder complicating pregnancyCoagulation func-tionHemodynamicMaternal-neonatal outcomes
万方数据
维普
