目的:探讨维生素D受体(VDR)基因FOKI位点多态性与子痫前期(PE)遗传易感性的关系.方法:计算机检索中国知网(CNKI)、万方、维普、中国生物医学文献数据库、PubMed、Web of Science中关于VDR基因FOKI位点多态性与PE易感性的病例对照研究,检索时间为建库至2023年5月.在等位基因模型(f比F)、纯合比较模型(ff比FF)、杂合比较模型(Ff比FF)、显性比较模型(Ff+ff比FF)和隐性比较模型(ff比FF+Ff)5种遗传模型下,采用Sta-ta11.0软件进行meta分析,并用OR值及95％可信区间(95％CI)评价VDR基因FOKI位点多态性与PE易感性之间的关联.结果:共纳入8篇文献,包括3446例研究对象.meta分析结果显示,在等位基因模型(f比F,OR=1.49,95％CI 1.08～2.05)、纯合比较模型(ff 比 FF,OR=1.80,95％CI 1.11～2.93)、隐性比较模型(ff 比 FF+Ff,OR=1.95,95％CI 1.39～2.73)下,VDR基因FOKI位点多态性与PE遗传易感性密切相关,而在杂合比较模型(Ff比FF)和显性比较模型(Ff+ff比FF)下,差异无统计学意义.结论:VDR基因FOKI位点可能与PE易感性有关,f等位基因和ff基因型可能是PE发生的危险因素.
Correlation between the polymorphism of vitamin D receptor FOKI site of pregnant women and their preeclampsia:A meta-analysis
Objective:To explore the correlation between the polymorphism of vitamin D receptor(VDR)gene FOKI site of pregnant women and their preeclampsia(PE)genetic susceptibility.Methods:The case-control studies that re-ported the correlation between the polymorphism of VDR gene FOKI site of pregnant women and their PE susceptibili-ty were searched by computer from the database,such as CNKI,Wanfang,VIP,China Biomedical Literature Data-base,PubMed and Web of Science,from the database established until May 2023.Meta-analysis was performed based on Stata 11.0 software under five genetic models:allele model(f vs F),homozygous comparison model(ff vs FF),heterozygous comparison model(Ff vs FF),dominant comparison model(Ff+ff vs FF)and recessive comparison model(ff vs FF+Ff).The correlation between the polymorphisms of VDR gene FOKI site of the pregnant women and their PE susceptibility was evaluated by the odds ratio(OR)and 95％confidence interval(CI).Results:A total of 8 studies were included in this meta-analysis,including 3,446 subjects.The results of the meta-analysis showed that the polymorphism of VDR gene FOKI site of the pregnant women was correlation with their PE genetic susceptibility in the allele model(f vs F)(OR=1.49,95％CI 1.08-2.05),in the homozygous comparison model(ff vs FF)(OR=1.80,95％CI 1.11-2.93)and in the implicit comparison model(ff vs FF+Ff)(OR=1.95,95％CI 1.39-2.73),but the poly-morphism of VDR gene FOKI site of the pregnant women was no significant correlation with their PE genetic susceptibility in the hybrid comparison model(Ff vs FF)and in the dominant comparison model(Ff+ff vs FF).Con-clusion:The polymorphism of VDR gene FOKI site of the pregnant women may be correlation with their PE suscepti-bility,and the f allele and ff genotype of the women may be the risk factors of their PE.
PreeclampsiaVitamin D receptorFOKI siteGene polymorphismMeta-analysis
万方数据
维普
