Value of the uterine artery flow parameters by Doppler ultrasonography combined with the levels of serum pro-angiogenic factor,serine protease inhibitor and endothelial cell specific molecule-1 for diagnosing hypertensive disorder of pregnancy
Objective:To analysis of the values of the uterine artery flow parameters by Doppler ultrasonography and the levels of serum pro-angiogenic factor(PIGF),serine protease inhibitor(Vaspin)and endothelial cell specific mole-cule-1(ESM-1)of pregnant women,and to study their diagnostic values for the hypertensive disorder of pregnancy(HDP)of the pregnant women.Methods:86 pregnant women with HDP from June 2020 to December 2021 were col-lected in study group retrospectively,and 75 healthy pregnant women were selected in control group.The levels of the serum PIGF,Vaspin and ESM-1,and the uterine artery blood flow parameters of the women in the two groups were detected,and the values of which for diagnosing HDP of the women were analyzed.Results:The serum level of PIGF(271.56±45.56 pg/ml)of the women in the study group was significantly lower than that(330.15±50.35 pg/ml)of the women in the control group.The levels of Vaspin(0.46±0.04 ng/ml)and ESM-1(1.38±0.51μg/L)of the women in the study group were significantly higher than those(0.39±0.08)ng/ml and 1.01±0.07μg/L)of the women in the control group.The values of uterine artery resistance index(RI,0.79±0.14),pulsatility index(PI,0.83±0.21),and the ratio of peak systolic velocity to end diastolic velocity(S/D,2.26±0.74)of the women in the study group were sig-nificantly higher than those(0.51±0.20,0.44±0.19 and 1.41±0.35)of the women in the control group.In the study group,there were significant differences in the levels of PIGF,Vaspin and ESM-1,and the values of RI,PI and S/D among the women with HDP,the women with mild preeclampsia and the women with severe preeclampsia(all P＜0.05).Receiver operating characteristic curve analysis showed that the area under the curve of the serum PIGF level,the serum Vaspin level,the serum ESM-1 level,and the RI value,the PI value,the S/D value,and the combination of the levels of PIGF,Vaspin and ESM-1,and the values of RI,PI and S/D of the women for the diagnosing their HDP were 0.811,0.780,0.691,0.944,0.860,0.813 and 0.999,respectively,the cut-off values of which were 291.56 pg/ml,0.43 ng/ml,1.12μg/L,0.58,0.53 and 1.87,respectively.The specificity and the accuracy of the combination of the levels of PIGF,Vaspin and ESM-1,and the values of RI,PI and S/D of the women for diagnosing their HDP were the highest,which were 96.5％and 93.4％(all P＜0.05).Conclusion:The levels of the serum PIGF,Vaspin and ESM-1,and the uterine artery blood flow parameters of the pregnant women with HDP are abnormal,and which have better diagnostic values for HDP of the women,and this study also provides a new idea for treating HDP by the targe-ted drugs.
Hypertension disorder of pregnancyDoppler ultrasoundUterine arterial blood flow parametersPro-an-giogenic factorSerine protease inhibitorEndothelial cell specific molecule-1Diagnostic value
万方数据
维普
