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早期子宫内膜癌药物治疗研究进展

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保留早期子宫内膜癌患者的生育能力是目前临床较为关注的问题,合理的药物治疗方法已被视为短期内替代传统手术的治疗选项,目前药物治疗主要包括孕激素、选择性雌激素受体调节剂、米非司酮、促性腺激素释放激素激动剂类似物、芳香化酶抑制剂和宫腔镜联合药物治疗等,已取得良好临床效果.但考虑到恶性肿瘤可再发的风险,在实际工作中需要对适应证进行合理分析,并在治疗后进行相关跟踪调查,以提升受孕率,同时,对肿瘤的预后也要给予足够的重视,以确保患者生命安全.本文就目前有关早期子宫内膜癌保留生育力的药物治疗的研究现状进行综述.
Research progress of the drug therapy of patients with early endometrial cancer
Preserving fertility of the patients with early endometrial cancer is currently a clinical concern,and the ra-tional drug therapy has been regarded as a short-term alternative to traditional surgery.Currently,the therapy drugs mainly include progesterone,selective estrogen receptor modulator,mifepristone,gonadotropin releasing hormone ag-onist analogue,aromatase inhibitor and hysteroscopy combined with drug therapy,and all of which have achieved the good application results.However,considering the risk of the recurrence of malignant tumors,it is necessary to make a reasonable analysis of the medicine indications during actual clinical work,and the relevant follow-up surveys of the patients after treatment should be carried out to improve their pregnancy rate.At the same time,the prognosis of the tumor of the patients should also be given enough attention to ensure the life safety of the patients.This article reviews the current research status of the drug therapy for the preserving fertility of the patients with early endometrial cancer.

Endometrial cancerFertility functionDrug therapyProgesteroneMifepristone

郑莹莹、田晓予、霍礼娜

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河南科技大学临床医学院,河南科技大学第一附属医院(洛阳,471003)

子宫内膜癌 生育功能 药物治疗 孕激素 米非司酮

2024

中国计划生育学杂志
国家人口计生委科学技术研究所

中国计划生育学杂志

CSTPCD
影响因子:1.759
ISSN:1004-8189
年,卷(期):2024.32(3)
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