Investigation of the correlation between the skewed X-chromosome inactivation of women and their recurrent spontaneous abortion:a meta-analysis
Objective:To investigate the correlation between the skewed X-chromosome inactivation(SXCI)of women and their recurrent spontaneous abortion(RSA).Methods:The databases,such as PubMed,Medline,Cochrane,CNKI,CBM and Wanfang,were searched by computer from the established database until June,2023 to collect the case-control studies about the correlation between SXCI of the women and their RSA.A meta-analysis was performed on the related-data of 3,706 women(1,673 women in case group and 2 033 women in control group)from 15 studies that were included after strict screening by Revman 5.3 and Stata 16.0 software.Results:In the overall analysis,the proportion of SXCI of the women in the case group was significantly higher than that of the women in the control group(OR=1.68,95％CI=1.29-2.18,P＜0.000).In the stratified analysis of the different degrees of SXCI,there was no statistical significance difference in the proportion of the moderate SXCI of the women between the two groups(OR=1.11,95％CI=0.56-2.18,P=0.760),while the proportions of the high SXCI(OR=2.32,95％CI=1.31-4.11,P=0.004)and the extreme SXCI(OR=4.71,95％CI=1.77-12.52,P=0.002)of the women in the case group were sig-nificantly higher than those of the women in the control group.In the stratified analysis of the women with different a-bortion numbers,the number of the miscarriages ≥2 times(OR=5.06,95％CI=2.46-10.40.P＜0.000)and the number of the miscarriages ≥3 times(OR=2.48,95％CI=1.66-3.68,P＜0.000)of the women in the case group had significantly higher proportions of the high SXCI and the extreme SXCI compared with those of the women in the con-trol group.Conclusion:The SXCI,especially the high SXCI or the extreme SXCI,of the women was significantly as-sociated with the increased risk of their RSA,and the more number of the miscarriages of the women,the greater association is likely to be.
万方数据
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