Risk factors associated with the acute bilirubin encephalopathy of neonates:a meta-analysis
Objective:To explore the risk factors associated with the acute bilirubin encephalopathy(ABE)of neonates by a meta-analysis,and to provide the theoretical evidences for the early identification and treatment of the neonatal ABE.Methods:The relevant studies were retrieved from the databases of Wanfang Data,CNKI,VIP,PubMed,Web of Science,Embase and Cochrane Library from the establishment time of these databases to August 1,2023.The liter-atures were screened according to the inclusion and exclusion criteria,and the relevant data in the included literatures were extracted.The meta-analysis was performed by RevMan 5.3 software.Results:Finally,30 clinical studies were included in this meta-analysis,and which involving 12,965 neonates.The meta-analysis results showed that a total of 15 risk factors were identified.The peak value of the total serum bilirubin(OR=1.27,95％CI 1.21-1.34),the total serum bilirubin/albumin ratio(OR=1.47,95％CI 1.21-1.79),the jaundice value within 24 hours(OR=6.03,95％CI 2.73-13.32),the ABO or Rh hemolysis rate(OR=3.31,95％CI 2.57-4.26),the high level of hemoglobin(OR=1.05,95％CI 1.01-1.11),the glucose-6-phosphate ehydrogenase deficiency rate(OR=3.82,95％CI 1.98-7.37),the perinatal hypoxia rate(OR=12.20,95％CI 1.95-76.27),the sepsis rate(OR=3.13,95％CI 1.98-4.95),the infection rate(OR=4.99,95％CI 3.58-6.97),the metabolic acidosis rate(OR=2.84,95％CI 1.64-4.91),the cerebral hemato-ma rate(OR=4.17,95％CI 2.39-7.27),the low birth weight rate(OR=3.31,95％CI:1.97-5.55),the rate of weight loss after birth(OR=1.08,95％CI 1.03-1.13),the lack of breast milk rate(OR=3.90,95％CI 1.97-7.74),and the non-hospital birth rate(OR=2.59,95％CI:1.93-3.45)of the neonates were the risk factors for their ABE occurrence.Conclusion:The 15 factors based on this meta-analysis are the risk factors of the neonatal ABE occurrence.However,more prospective studies with large samples,multiple centers,and accuracy are still needed to conduct for further veri-fying these risk factors of the neonatal ABE occurrence.
万方数据
维普
