Evaluation of the levels of serum amyloid A and interferon-γ and the uterine artery blood flow parameters of pregnant women for their unexplained recurrent abortion
Objective:To analyze the levels of serum amyloid A(SAA)and interferon y(IFN-y)and the uterine artery blood flow parameters of pregnant women with unexplained recurrent abortion(URSA),and to study the levels of ser-um SAA and IFN-γand the uterine artery blood flow parameters of the women for predicting their URSA.Methods:102 pregnant women with URSA were prospectively selected in observation group and 98 normal pregnant women were selected in control group from February 2021 to February 2023.The serum levels of SAA and IFN-γ and the uterine ar-tery blood flow parameters of the women were compared between the two groups.The women in the two groups were followed up to 28 gestational weeks.Multivariate logistic regression was used to analyze the risk factors affecting the pregnancy outcomes of the women with URSA.Receiver operating characteristic(ROC)curve was drawn to analyze the values of the serum SAA and IFN-γ levels,and the uterine artery blood flow parameters of the women for evalua-ting their pregnancy outcomes.Results:The levels of serum SAA(33.38±10.07 mg/L)and IFN-γ(155.98±5.81 pg/ml)of the women in the observation group were significantly higher than those(8.67±1.08 mg/L and 28.55±1.53 pg/ml)of the women in the control group.The uterine artery blood flow parameters values of the women in the observa-tion group were significantly higher than those of the women in the control group(all P＜0.05).There were 76 cases with successful pregnancy till to 28 gestational weeks in group A and 26 cases with abortion in group B during the fol-low-up.The number of abortions,the serum SAA and IFN-y levels,the values of the resistance index(RI),the peak systolic flow velocity/diastolic flow velocity(S/D)of the women in group B were significantly higher than those of the women in group A.Logistic regression analysis showed that the increase of the serum SAA and IFN-γ levels,and the values of RI and S/D of the women with URSA were the influencing factors of their pregnancy outcomes(all P＜0.05).ROC curve analysis showed that the area under the curve of the levels of SAA and IFN-y combined with the values of RI and S/D of the women for predicting their pregnancy outcomes was 0.762(95％CI 0.637-0.814),with a sensitivity of 92.6％and a specificity of 91.2％,and the predictive efficacy of which was significantly higher than that of the SAA level,the IFN-γ level,the RI value or the S/D value alone(P＜0.05).Conclusion:The levels of serum SAA and IFN-γ and the values of uterine artery blood flow parameters of the pregnant women with URSA are signifi-cantly increased,which all have the better clinical values for predicting the pregnancy outcomes of the women.
万方数据
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