首页|补肾增液汤加减联合左卡尼汀对弱精子症患者精液参数及IVF-ET相关指标的影响

补肾增液汤加减联合左卡尼汀对弱精子症患者精液参数及IVF-ET相关指标的影响

Effects of the dialectical Bushenzengye decoction combined with L-carnitine for treating patients with asthenospermia on their semen parameters and the related indexes of their in vitro fertilization and embryo transplantation

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目的:探究补肾增液汤辩证加减联合左卡尼汀对弱精子症患者精液参数、体外受精-胚胎移植(IVF-ET)指标的影响.方法:收集2020年1月-2022年1月在本院中心行IVF周期治疗弱精子症94例临床资料,按治疗方式分为对照组(n=41例,左卡尼汀治疗)与联合组(n=53例,补肾增液汤辩证加减联合左卡尼汀治疗),疗程12周,比较两组治疗效果、治疗前后精液质量分析、性功能及IVF周期相关指标.结果:治疗后,联合组精液量(3.71±0.75ml)、精子浓度(30.05±5.75)106个/ml、精子存活率(58.63±10.14)%、a+b级精子率(66.65±10.45)%均高于对照组[(3.08 ±0.89ml、(27.63±5.07)106 个/ml、(53.17±8.45)%、(60.74±8.71)%];勃起信心(3.65±0.46 分)、勃起时间(3.89± 0.35分)、勃起维持时间(3.63±0.45分)、性交困难(4.35±0.25分)、性满足(4.05±0.21分)及总分(19.57±1.72分)均高于对照组(3.37±0.31 分、3.41±0.29 分、3.23±0.23 分、4.11±0.16 分、3.33±0.15 分、17.45±1.14 分);受精率(82.8 ±5.1)%、优质胚胎率(56.9±10.3)%、可移植胚胎数目(2.4±0.5个)及临床妊娠率(60.0%)均高于对照组[(81.0± 3.7)%、(48.5±8.0)%、1.5±0.5 个、37.5%];治疗总有效率(90.6%)高于对照组(73.2%)(均 P<0.05).结论:补肾增液汤辩证加减联合左卡尼汀可提高弱精子症患者精液质量,改善患者性功能,有利于改善IVF-ET周期指标,提高IVF-ET成功率.
Objective:To explore the effects of the dialectical Bushenzengye decoction combined with L-carnitine for treating patients with asthenospermia on their semen parameters and the related indexes of their in vitro fertilization.Methods:94 patients with asthenospermia who wanted the treatment of IVF cycle were selected and were divided into control group(41 cases with the treatment of L-carnitine for 12 weeks)and the study group(53 cases with the treat-ment of the dialectical Bushenzengye decoction combined with L-carnitine for 12 weeks)according to the different treatment methods from January 2020 to January 2022.The treatment effect,the semen quality analysis before and af-ter treatment,the sexual function and IVF cycle related indexes of the patients were compared between the two groups.Results:The semen volume(3.71±0.75ml),the sperm concentration(30.05±5.75 106 cells/ml),the sperm survival rate(58.63±10.14%),the rate of the a+b level sperm(66.65±10.45%)of the patients in the study group after treatment were significantly higher than those(3.08±0.89ml,27.63±5.07 106 cells/ml,53.17±8.45%and 60.74± 8.71%)of the patients in the control group.The scores of the erection confidence(3.65±0.46 points),the erection time(3.89±0.35 points),the erection maintenance time(3.63±0.45 points),the difficulty of sexual intercourse(4.35 ±0.25 points),the sexual satisfaction(4.05±0.21 points)and the total score(19.57±1.72 points)of the patients in the study group were significantly higher than those(3.37±0.31points,3.41±0.29 points,3.23±0.23 points,4.11± 0.16 points,3.33±0.15 points and 17.45±1.14 points)of the patients in the control group.The fertilization rate(82.8 ±5.1%),the high-quality embryo rate(56.9±10.3%),the number of transferrable embryos(2.4±0.5 pieces)and the clinical pregnancy rate(60.0%)of the patients in the study group were significantly higher than those(81.0± 3.7%,48.5±8.0%,1.5±0.5 pieces and 37.5%)of the patients in the control group.The total effective rate(90.6%)of the patients in the study group was significantly higher than that(73.2%)of the patients in the control group(all P<0.05).Conclusion:The dialectical Bushenzengye decoction combined with L-carnitine for treating the patients with asthenospermia can improve their semen quality and sexual function,and which is conducive to improving the indica-tors related to IVF cycle and increasing the success rate of IVF.

AsthenospermiaL-carnitineBushenzengye decoctionSemen qualitySexual functionIn vitro fertiliza-tion and embryo transplantation

马秀丽、贾蓉

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江苏省常州市武进中医医院(213161)

弱精子症 左卡尼汀 补肾增液汤 精液质量 性功能 体外受精-胚胎移植

2024

中国计划生育学杂志
国家人口计生委科学技术研究所

中国计划生育学杂志

CSTPCD
影响因子:1.759
ISSN:1004-8189
年,卷(期):2024.32(4)
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