Effects of remifentanil combined with ciprofol for anesthesia during laparoscopic myomectomy of patients on their hemody-namic parameters and inflammatory factors levels
Objective:To explore the effects of remifentanil combined with ciprofol for anesthesia during laparoscopic myomectomy of patients on their hemodynamic parameters and inflammatory factors levels.Methods:110 patients who wanted laparoscopic myomectomy were randomly divided into group A and group B(55 cases in each group)from October 2022 to September 2023.The patients in group A received anesthesia with remifentanil combined with ciprofol during operation,while the patients in group B received anesthesia with remifentanil combined with propofol during op-eration.The hemodynamic indicators,the awakening quality,the inflammatory factor levels,the cognitive function(MMSE score)and the adverse reactions of the patients in the two groups were observed.Results:The values of the mean arterial pressure,the heart rate and the blood oxygen saturation of the patients in group A were significantly higher than those of the patients in group B.The time of the spontaneous breathing recovery(5.25±1.29 min),the a-wakening time(7.21±1.86 min),the orientation recovery time(20.56±2.83 min)and the extubation time(24.37± 3.01 min)of the patients in group B were significantly shorter than those(7.33±1.85 min,12.82±2.23 min,25.38± 3.71 min and 32.62±3.67 min)of the patients in group B.The levels of interleukin-6 and tumor necrosis factor-α of the patients in the two groups in 1 day after operation had increased significantly,but which(71.53±10.02 ng/L and 12.23 ±2.96 ng/L)of the patients in group A were significantly lower than those(90.24±12.84 ng/L and 17.65±3.58 ng/L)of the patients in group B.The MMSE score of the patients in the two groups had decreased significantly,but which(27.04±1.00 points)of the patients in group A was significantly higher than that(25.15±1.17 points)of the patients in group B.The incidence of the adverse reactions(5.5％)of the patients in group A was significantly lower than that(18.2％)of the patients in group B(all P＜0.05).Conclusion:The application of remifentanil combined with ciprofol in the laparoscopic uterine myomectomy of the patients can help to stabilize their intraoperative hemodynamic indica-tors,improve their awakening quality,reduce their inflammatory reactions and cognitive impairment,and with the fe-wer adverse reactions.
万方数据
维普
