Coagulation factor Ⅷ activity and plasminogen activator inhibitor-1 level of pregnant women with threatened miscarriage during the first trimester of pregnancy and their influence on the tocolytic outcomes
Objective:To investigate the predictive value of the coagulation factor Ⅷ(FⅧ)activity and plasminogen activator inhibitor-1(PAI-1)level of pregnant women with threatened miscarriage during the first trimester of preg-nancy for their tocolytic outcomes.Methods:The clinical data of 345 pregnant with threatened miscarriage during the first trimester of pregnancy from January 2020 to December 2022 were analyzed retrospectively.According to the toco-lytic outcomes,these women were divided into group A(124 cases with the failure of tocolytic outcomes)and group B(221 cases with the successful tocolytic outcomes).The FⅧ activity and the levels PAI-1,beta human chorionic gon-adotropin(β-hCG),serum estradiol(E2)and progesterone(P)of the women in the two groups were detected.The en-dometrial thickness(ET)of the women in the two groups was examined by ultrasound.Multivariate logistic regression analysis was conducted to identify the influencing factors of the successful tocolytic outcomes of the pregnant women with threatened miscarriage during the first trimester of pregnancy.Results:The FⅧ activity(168.31±25.84％)and the PAI-1 level(54.39±6.05μg/l)of the women in group A were significantly higher than those(138.64±24.61％and 49.31±5.87μg/l)of the women in group B.The ET value(10.06±3.26 mm)and the levels of β-hCG(1763.86± 706.77U/L),E2(1051.16±369.57 poml/L)and P(32.96±15.72 noml/L)of the women in group A were significantly lower than those(12.55±1.91 mm,3299.46±1831.59U/L,3571.36±1126.29 poml/L and 64.38±17.24 noml/L)of the women in group B(all P＜0.05).Multivariate logistic regression analysis showed that the increase of the FⅧ ac-tivity and the decrease of the levels of β-hCG,E2 and P were risk factors for the successful tocolytic outcomes of the pregnant women with threatened miscarriage during the first trimester of pregnancy(P＜0.05),while the PAI-1 level was not a risk factor for their successful tocolytic outcomes.Conclusion:The increase of FⅧ activity of the pregnant women with threatened miscarriage during the first trimester of pregnancy affects their success of tocolysis,which can be used as a reference,so as to reduce the risk of the blind tocolysis in clinical practice.
The first trimester of pregnancyThreatened miscarriageTocolysisCoagulation factor ⅧPlasmino-gen activator inhibitor-1Influence factor
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