摘要
目的:探讨白细胞介素-6(IL-6)、降钙素原(PCT)及纤维蛋白原在卵巢囊肿蒂扭转患者血清中表达及其诊断价值.方法:收集2020年1月-2022年12月本院收治的女性卵巢囊肿蒂扭转患者106例、未发生卵巢囊肿蒂扭转患者82例临床资料,根据术后病理结果将观察组分为正常组和坏死组,比较分析各组血清IL-6、PCT、纤维蛋白原水平及其诊断卵巢囊肿蒂扭转价值.结果:观察组IL-6(12.8±0.6 pg/ml)、PCT(0.6±0.1 ng/ml)、纤维蛋白原(3.0±0.8 g/L)水平均高于对照组(8.2±0.3 pg/ml、0.1±0.0 ng/ml、1.2±0.4 g/L),且观察组中坏死组水平高于正常组(均P＜0.05);受试者工作特征曲线分析,IL-6、PCT纤维蛋白原单独或联合应用诊断卵巢囊肿蒂扭转的曲线下面积分别为0.811、0.891,0.635、0.953,联合诊断的敏感度98.1％、特异度92.3、准确率89.8％.结论:IL-6、PCT及纤维蛋白原联合应用对卵巢囊肿蒂扭转的鉴别诊断价值较高,可用于指导临床.
Abstract
Objective:To investigate the expressions of interleukin 6(IL-6),procalcitonin(PCT)and fibrinogen of pa-tients with torsion of ovarian cyst,and to study their diagnostic values.Methods:The clinical data of 106 patients with ovarian cyst torsion(in study group)and 82 patients without ovarian cyst torsion(in control group)admitted to hospi-tal from January 2020 to December 2022 were collected.The patients in the study group were divided into group A(pa-tients with ovarian cyst necrosis)and group B(patients without ovarian cyst necrosis)according to the postoperative pathological results of the patients.The expression levels of IL-6,PCT and fibrinogen of the patients were compared a-mong these groups,and their diagnostic values for the ovarian cyst torsion was analyzed.Results:The levels of IL-6(12.8±0.6 pg/ml),PCT(0.6±0.1 ng/ml)and fibrinogen(3.0±0.8 g/L)of the patients in the study group were sig-nificantly higher than those(8.2±0.3 pg/ml,0.1±0.0 ng/ml and 1.2±0.4 g/L)of the patients in the control group,and which of the patients in group A were significantly higher than those of the patients in group B(all P＜0.05).Re-ceiver operating characteristic curve analysis showed that the area under the curve of the IL-6 level,the PCT level,the fibrinogen level or the combination levels of IL-6,PCT and fibrinogen of the patients with ovarian cyst for diagnosing their torsion of ovarian cyst was 0.811,0.891,0.635 or 0.953,respectively.The sensitivity,the specificity and the ac-curacy of the combination levels of iIL-6,PCT and fibrinogen of the patients with ovarian cyst for diagnosing the tor-sion of their ovarian cyst were 98.1％,92.3 and 89.8％,respectively.Conclusion:The combined levels of IL-6,PCT and fibrinogen of the patients with ovarian cyst for diagnosing their torsion of ovarian cyst has higher value,which can be used to guide the clinical practice.
维普
万方数据