Correlation between the vaginal flora changes of pregnant women with premature rupture of membranes during the third trimester of pregnancy and their adverse pregnancy outcomes
Objective:To analyze the correlation between the vaginal flora changes of pregnant women with premature rupture of membranes(PROM)during the third trimester of pregnancy and their adverse pregnancy outcomes.Meth-ods:The clinical data of 128 pregnant women with PROM during the third trimester of pregnancy(in study group)and 90 healthy pregnant women with normal prenatal examination(in control group)from May 2022 to September 2023 were collected retrospectively.The general data,the microbial distribution and constituent in vaginal secretions and the vaginal microecology of the women were compared between the two groups.The pregnancy outcomes were compared among the women with different vaginal microecology status.Results:The levels of the vaginal gram-posi-tive bacilli,lactobacillus and Gram-positive cocci of the women in the study group were significantly lower than those of the women in the control group,but the levels of the vaginal proteusbacillus vulgaris,enterobacter cloacae and staphylococcus haemolyticus of the women in the study group were significantly higher than those of the women in the control group(all P＜0.05).There was no significant difference in the distribution of other vaginal microorganisms of the women between the two groups(P＞0.05).There were significant differences in the density of vaginal flora and the diversity of vaginal flora of the women between the two groups.The proportion of the microecological imbalance(46.9％)of the women in the study group was significantly higher than that(32.2％)of the women in the control group(P＜0.05),but there was no significant difference in the vaginal PH value of the women between the two groups(P＞0.05).In the study group,the preterm birth rate(15.0％)and the neonatal infection rate(15.0％)of the women with the vaginal microecology disorder were significantly higher than those(2.9％and 4.4％)of the women with normal vaginal microecology(all P＜0.05).Conclusion:The vaginal flora density and diversity,and the vaginal microecology of the pregnant women with PROM during the third trimester of pregnancy are abnormal comparing to those of the normal pregnant women.The vaginal microecological imbalance of the pregnant women with PROM will increase the risk of their adverse pregnancy outcomes.
The third trimester of pregnancyPremature rupture of membranesVaginal floraMicroecologyAd-verse pregnancy outcomes
万方数据
维普
