Correlation between the expressions of the estrogen receptor,progesterone receptor and human epidermal growth factor re-ceptor 2 of patients with breast cancer and their magnetic resonance imaging(MRI)signs
Objective:To explore the correlation between the expressions of the estrogen receptor(Er),progesterone receptor(Pr)and human epidermal growth factor receptor 2(Her2)of patients with breast cancer and their magnetic resonance imaging(MRI)signs.Methods:The clinical data of 125 patients with breast cancer who had been operated in hospital from January 2021 to December 2022 were analyzed retrospectively.These patients underwent MRI exami-nation in 1 to 2 weeks after menstruation.The MRI signs of the lesions of the patients were analyzed and diagnosed by two associate chief physicians according to the results of MRI examination of the patients.The MRI signs included the tumor diameter,the tumor morphology,the enhancement pattern,the tumor margin,the early enhancement rate and the time-signal intensity curve(TIC).The expressions of the ER,PR and Her2 in tumor tissues were detected by im-munohistochemical SP method.Results:The MRI examination showed that the positive expression rate of PR of the patients was different among the patients with different tumor diameter,margin,shape or TIC,and the positive ex-pression rate of ER of the patients was different among the patients with different tumor morphology or TIC(all P＜0.05).There was no significant difference in the positive expression rates of ER,PR and Her2 among the patients with different other MRI signs(P＞0.05).The tumor margin of MRI signs of the patients was negatively correlated with their ER and Her2 positive expressions(P＜0.05),and the early enhancement pattern of the patients was negatively correlated with their Her2 positive expression(P＜0.05).The other MRI signs of the patients had no significant correlation with the positive expression rates of their ER,PR and Her2(P＞0.05).Conclusion:The levels of the ER,PR and Her2 of the patients are correlated with their MRI signs of the breast cancer,such as the tumor diameter,the tumor morphology,the tumor margin and the enhancement pattern.The MRI features of the breast cancer of the pa-tients can be used as the preliminary evaluations of the histopathological changes of their breast cancer,and which can provide the references for the clinical diagnosis,treatment and prognosis evaluation of the breast cancer of the patients.
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