Correlation between the squamous-cell carcinoma antigen level and neutrophil to lymphocyte ratio of women with cervical cancer and their clinicopathological characteristics and prognosis
Objective:To explore the correlation between the squamous-cell carcinoma antigen(SCC-Ag)level and neu-trophil to lymphocyte ratio(NLR)of women with cervical cancer and their clinicopathological characteristics and prog-nosis.Methods:108 women with cervical cancer in group A,108 women with cervical intraepithelial neoplasia(CIN)in group B and 108 healthy women in group C were enrolled in this study.The levels of SCC-Ag and NLR of the women were compared among the three groups.The correlation between the levels of SCC-Ag and NLR of women in group A and their clinicopathological characteristics and prognosis was analyzed.Results:The levels of serum SCC-Ag and NLR of the women in group A(7.35±1.76 and 4.65±1.06),in group B(2.06±0.53 and 3.41±0.89),and in group C(0.54±0.12 and 1.53±0.34)had decreased gradually(P＜0.05).The levels of the serum SCC-Ag and NLR of the women with cervical cancer were related to their pathological type,FIGO stage,pathological grade,depth of myometrial inva-sion and pelvic lymph node metastasis(P＜0.05).Kaplan-Meier showed that the overall survival rate and the disease-free survival rate of the women with the high expressions of SCC-Ag and NLR were significantly lower than those of the women with the low expressions of SCC-Ag and NLR.The overall survival rate and the disease-free survival rate of the women with high expressions of SCC-Ag and NLR were the lowest(all P＜0.05).Conclusion:The levels of serum SCC-Ag and NLR of the women with cervical cancer are related to their pathological type,FIGO staging,pathological grading and depth of muscular invasion.The higher of the levels of serum SCC-Ag and NLR,the worse of the progno-sis of the women.
万方数据
维普
