中国计划生育学杂志2024，Vol.32Issue(5) ：1067-1071.DOI:10.3969/j.issn.1004-8189.2024.05.017

宫颈癌患者血清SCC-Ag、NLR水平与临床病理特征及预后关系

Correlation between the squamous-cell carcinoma antigen level and neutrophil to lymphocyte ratio of women with cervical cancer and their clinicopathological characteristics and prognosis

陈秀英 陈娜 高娜 崔建涛 李晓丹 张士表
中国计划生育学杂志2024，Vol.32Issue(5) ：1067-1071.DOI:10.3969/j.issn.1004-8189.2024.05.017
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  • 维普
  • 万方数据

宫颈癌患者血清SCC-Ag、NLR水平与临床病理特征及预后关系

Correlation between the squamous-cell carcinoma antigen level and neutrophil to lymphocyte ratio of women with cervical cancer and their clinicopathological characteristics and prognosis

陈秀英 1陈娜 1高娜 1崔建涛 1李晓丹 1张士表1
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作者信息

  • 1. 河北省沧州中西医结合医院(061000)
  • 折叠

摘要

目的:探讨宫颈癌患者血清鳞状细胞癌抗原(SCC-Ag)、中性粒细胞与淋巴细胞比值(NLR)与临床病理特征及预后关系.方法:纳入2018年1月—2023年1月本院收治的108例宫颈癌患者为宫颈癌组,宫颈上皮内瘤病变(CIN)患者108例为CIN组,健康体检健康女性108例为对照组.比较3组血清SCC-Ag、NLR水平,分析宫颈癌组血清SCC-Ag、NLR水平与临床病理特征及与预后关系.结果:血清SCC-Ag、NLR水平,宫颈癌组(7.35±1.76、4.65±1.06)、CIN 组(2.06±0.53、3.41±0.89)、对照组(0.54±0.12、1.53±0.34)依次降低(P＜0.05).宫颈癌患者血清SCC-Ag、NLR水平与病理类型、FIGO分期、病理分级、肌层浸润深度和盆腔淋巴结转移有关(P＜0.05).Kaplan-Meier显示,SCC-Ag、NLR高表达组总生存率、无病生存率均低于SCC-Ag、NLR低表达组,SCC-Ag高表达+NLR高表达组总生存率、无病生存率最低(均P＜0.05).结论:宫颈癌患者血清SCC-Ag、NLR水平与病理类型、FIGO分期、病理分级和肌层浸润深度等有关,且SCC-Ag、NLR水平越高患者预后越差.

Abstract

Objective:To explore the correlation between the squamous-cell carcinoma antigen(SCC-Ag)level and neu-trophil to lymphocyte ratio(NLR)of women with cervical cancer and their clinicopathological characteristics and prog-nosis.Methods:108 women with cervical cancer in group A,108 women with cervical intraepithelial neoplasia(CIN)in group B and 108 healthy women in group C were enrolled in this study.The levels of SCC-Ag and NLR of the women were compared among the three groups.The correlation between the levels of SCC-Ag and NLR of women in group A and their clinicopathological characteristics and prognosis was analyzed.Results:The levels of serum SCC-Ag and NLR of the women in group A(7.35±1.76 and 4.65±1.06),in group B(2.06±0.53 and 3.41±0.89),and in group C(0.54±0.12 and 1.53±0.34)had decreased gradually(P＜0.05).The levels of the serum SCC-Ag and NLR of the women with cervical cancer were related to their pathological type,FIGO stage,pathological grade,depth of myometrial inva-sion and pelvic lymph node metastasis(P＜0.05).Kaplan-Meier showed that the overall survival rate and the disease-free survival rate of the women with the high expressions of SCC-Ag and NLR were significantly lower than those of the women with the low expressions of SCC-Ag and NLR.The overall survival rate and the disease-free survival rate of the women with high expressions of SCC-Ag and NLR were the lowest(all P＜0.05).Conclusion:The levels of serum SCC-Ag and NLR of the women with cervical cancer are related to their pathological type,FIGO staging,pathological grading and depth of muscular invasion.The higher of the levels of serum SCC-Ag and NLR,the worse of the progno-sis of the women.

关键词

宫颈癌/鳞状细胞癌抗原/中性粒细胞与淋巴细胞比值/病理特征/预后

Key words

Cervical cancer/Squamous cell carcinoma antigen/Neutrophil lymphocyte ratio/Pathological characteris-tic/Prognosis

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基金项目

河北省卫生健康项目(20232140)

出版年

2024
中国计划生育学杂志
国家人口计生委科学技术研究所

中国计划生育学杂志

CSTPCD
影响因子：1.759
ISSN：1004-8189
参考文献量22
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