Analysis of the human papillomavirus(HPV)infection factors of patients with cervical cancer and the genotype distribu-tion of HPV
Objective:To analyze the infection status of human papillomavirus(HPV)of patients with cervical cancer,and to study the genotype distribution of HPV.Methods:The clinical data of 351 patients with cervical cancer who vis-ited hospital from January 2021 to December 2023 were selected in this study.The HPV infection status and the geno-type distribution of HPV of the patients were analyzed.Logistic regression analysis was applied to screen the independ-ent risk factors of HPV infection of the patients with cervical cancer.Results:Among 351 patients with cervical canc-er,there were 336(95.7％)cases with HPV infection.There were significant differences in the number of sexual part-ners and the history of cervicitis between the patients with and without HPV infection(P＜0.05).Logistic regression analysis showed that the number of sexual partners ≥2 people and the history of cervicitis of the patients with cervical cancer were the independent risk factors of their HPV infection.Among 336 patients with HPV infection,there 239(71.1％)cases with the single HPV infection and 97 cases(28.9％)cases with the mixed infection of HPV,including 71(21.1％)cases with double HPV infection and 26(7.7％)cases with multiple HPV infection.There was significant difference in the single HPV infection rate among the patients with different pathological types of the cervical cancer,among the patients with different clinical stages of the cervical cancer,among the patients with different differentiation degrees of the cervical cancer cell and among the patients with different lymph node metastasis situations.There was significant difference in the mixed HPV infection rate among the patients with different clinical stages of the cervical cancer,among the patients with different differentiation degrees of the cervical cancer cell and among the patients with different lymph node metastasis situations.There was significant difference in the total HPV infection rate among the patients with different pathological types of the cervical cancer and among the patients with different clinical stages of the cervical cancer(all P＜0.05).Among 239 cervical cancer patients with single HPV infection,there were 233(97.5％)cases with high-risk HPV subtypes infection,and the top three infection rates of the HPV subtypes were HPV16(45.8％),HPV18(6.8％)and HPV58(4.8％).Conclusion:This study shows that the patients with cervical cancer have the higher HPV infection rate.The number of sexual partners ≥2 people and the history of cervicitis of the patients with cervical cancer can increase their HPV infection risk.The HPV infection of the patients with cervical cancer is mainly the single HPV infection,the top three genotypes of HPV subtypes infection are HPV 16,HPV 18,and HPV 58.
Cervical cancerHuman papillomavirusGenotypeRisk factor of Infection
万方数据
维普
