Correlation between the levels of interleukin-17 and nuclear transcription factor-κin peripheral blood of pregnant women with gestational condyloma acuminatum during pregnancy and their pregnancy outcomes
Objective:To analyze the correlation between the levels of interleukin-17(IL-17)and nuclear transcription factor-κ(NF-κB)in peripheral blood of pregnant women with gestational condyloma acuminatum during pregnancy and their pregnancy outcomes.Methods:A total of 137 patients with gestational condyloma acuminatum admitted to hospi-tal from September 2014 to September 2023 were included in observation group retrospectively.According to the matc-hing principle of gender and age by 1∶1 ratio,137 healthy pregnant women who received routine pregnancy examination in the hospital during the same period were selected in control group.The pregnancy outcomes,and the IL-17 and NF-κB levels in peripheral blood of the women in the two groups were counted.The women in the observation group were divided into group A(the women with normal pregnancy outcomes)and group B(the women with adverse pregnancy outcomes)according to the pregnancy outcomes of the women.The clinical data and the IL-17,NF-κB levels in periph-eral blood of the women were compared between group A and group B.The correlation between the IL-17 and NF-κB levels in peripheral blood of the women with gestational condyloma acuminatum and their pregnancy outcomes was analyzed by logistic regression.Receiver operating characteristic(ROC)curve was used to analyze the value of the IL-17 and NF-κB levels in peripheral blood of the women with gestational condyloma acuminatum for evaluating their pregnancy outcomes.Results:There was no any woman with postpartum hemorrhage in these groups.The cesarean section rate(37.2％)and the total incidence of adverse pregnancy outcomes(13.9％)of the women in the observation group were significantly higher than those(1.5％and 0)of the women in the control group.The levels of IL-17(91.27±28.33 pg/ml)and NF-κB(8.66±4.05 ng/ml)in peripheral blood of the women in the observation group were signif-icantly higher than those(15.31±4.04 pg/ml and 4.22±1.63 ng/ml)of the women in the control group.Among 137 women in the observation group,there were 19 cases in group B and 118 cases in group A,and there were no signifi-cant differences in the age,the gestational weeks,the previous pregnancy history,the number and area of condyloma acuminatum,and HPV typing of the women between group A and group B(P＞0.05).The levels of IL-17(121.20±16.90 pg/ml)and NF-κB(14.87±4.60 ng/ml)of the women in group B were significantly higher than those(86.45±30.17 pg/ml and 7.66±3.96 ng/ml)of the women in group A(all P＜0.05).Logistic regression analysis showed that the levels of IL-17 and NF-κB in peripheral blood of the women with condyloma acuminatum were the risk factors of their adverse pregnancy outcomes(P＜0.05).ROC curve showed that the area under the curve of the NF-κB level(0.949)of the women with condyloma acuminatum for evaluating their pregnancy outcomes was significantly higher than that(0.884)of the IL-17 level.The specificity of the combined levels of IL-17 and NF-κB of the women with con-dyloma acuminatum for evaluating their pregnancy outcomes was 97.5％.Conclusion:The levels of IL-17 and NF-κB in peripheral blood of the women with gestational condyloma acuminatum are abnormally elevated,and these women have the higher risk of adverse pregnancy outcomes,and the levels of IL-17 and NF-κB in peripheral blood of the women are related to their pregnancy outcomes.The combined levels of IL-17 and NF-κB of the women with condyloma acumina-tum for evaluating their pregnancy outcomes has the advantages of high sensitivity,and which is worthy of clinical at-tention.
万方数据
维普
