Effects of preemptive analgesia by flurbiprofen ester during hysteroscopic surgery of patients on their indexes of postopera-tive pain and inflammation response
Objective:To explore the effects of preemptive analgesia by flurbiprofen ester during hysteroscopic surgery of patients on their indexes of postoperative pain and inflammation response.Methods:A total of 138 patients who wanted hysteroscopic surgery were selected and were divided into two groups(69 cases in each group)according to random odd-even method from January 2022 to January 2024.The patients in the control group were given general an-esthesia,and the patients in the observation group were given preemptive analgesia by flurbiprofen ester combined with the general anesthesia.The levels of intraoperative hemodynamic indexes,the anesthetic effect,the postoperative pain score,the inflammation indexes levels and the adverse reactions rate of the patients were compared between the two groups.Results:The values of heart rate(HR)and mean arterial pressure(MAP)of the patients in both groups at the time of cervical dilation(T1)and before the completion of operation(T2)were significantly higher than those of the patients before anesthesia induction treatment(T0),and the values of HR and MAP of the patients in the observa-tion group at T1 and T2 were significantly lower than those of the patients in the control group.The dosage of propofol used(213.28±2.43 mg)and the wake-up time(3.12±0.75 min)of the patients in the observation group were signifi-cantly less than those(248.83±2.17 mg and 7.53±1.22 min)of the patients in the control group.The pain scores of the patients in the observation group at 2h,12h and 24h after operation(1.53±0.36 points,2.49±0.74 points and 1.86±0.53 points)were significantly lower than those(3.72±0.65 points,4.65±1.18 points and 3.51±0.62 points)of the patients in the control group.The levels of serum interleukin-6,prostaglandin E2,tumor necrosis factor-α and sub-stance P of the patients in the observation group were significantly lower than those of the patients in the control group(all P＜0.05).There was no significant difference in the incidence of adverse reactions(5.8％vs.10.1％)of the patients between the two groups(P＜0.05).Conclusion:Preemptive analgesia by flurbiprofen ester during hystero-scopic surgery of the patients can help reduce their postoperative pain and inflammatory responses,and improve their clinical effect,and with the medication safety.
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