Influencing factors of the adverse pregnancy outcomes of patients with intrahepatic cholestasis of pregnancy
Objective:To explore the possible influencing factors of the adverse pregnancy outcomes of patients with in-trahepatic cholestasis of pregnancy(ICP).Methods:The clinical data of 225 patients with ICP admitted to the hospital from January 2018 to January 2023 were collected.The basic information and the hematological indicators values of the patients were collected,and the patients were followed up for 12 months.Logistic regression was used to analyze the possible influencing factors of the adverse pregnancy outcomes of the patients.Receiver operating characteristic(ROC)curve was plotted to evaluate the efficacy of the influencing factors for predicting the adverse pregnancy outcomes of the patients.Results:The incidence of the adverse pregnancy outcomes of the patients with ICP was 37.8％(85/225).Lo-gistic regression analysis showed that the abnormally increased serum glycholic acid level and the total bile acid level and the albumin/alkaline phosphatase ratio of the patients with ICP were the independent influencing factors of their adverse pregnancy outcomes.ROC curve analysis showed that the area under the curve(AUC)of the serum glycholic acid level,the total bile acid level,the albumin/alkaline phosphatase ratio,and the combined the serum glycholic acid level,the total bile acid level and the albumin/alkaline phosphatase ratio of the patients with ICP for predicting their adverse pregnancy outcomes were 0.692,0.713,0.689 and 0.876,respectively.Conclusion:The abnormally increased serum glycholic acid level,the total bile acid level and the albumin/alkaline phosphatase ratio of the patients with ICP are the independent influencing factors of their adverse pregnancy outcomes,and which have certain efficacy for predic-ting the adverse pregnancy outcomes of the patients.
Intrahepatic cholestasis of pregnancyGlycholic acidTotal bile acidAlbumin/alkaline phosphatase ratioAdverse pregnancy outcomesInfluence factorPrediction
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