Levels of the serum transforming growth factor-β1,interleukin-2 and matrix metalloproteinase-9 of women with tubal ob-structive infertility and their clinical significance
Objective:To analyze the levels changes of the serum transforming growth factor-β1(TGF-βi),interleukin-2(IL-2)and matrix metalloproteinase-9(MMP-9)of the women with tubal obstructive infertility,and to study their clinical significance.Methods:A total of 60 women with tubal obstructive infertility diagnosed and treated in the hospi-tal were selected in study group and 50 women with normal pregnancy and delivery were selected in control group from March 2022 to October 2023.The serum TGF-β1,IL-2 and MMP-9 levels of the women were measured and compared between the two groups,and the correlation among which was analyzed by Pearson correlation analysis.Receiver oper-ating characteristic(ROC)curve was used to analyze the diagnostic efficacy of the serum TGF-β1,IL-2 and MMP-9 levels of the women for their infertility,and the influencing factors of the tubal obstructive infertility of the women were analyzed by logistic multivariate regression.Results:The preoperative levels of the serum TGF-β1(593.79±148.23 ng/L),IL-2(3.90±0.75 ng/L)and MMP-9(384.88±86.87 ng/ml)of the women in the study group were significantly higher than those(239.42±113.37 ng/L,3.09±0.84 ng/L and 178.98±80.85 ng/ml)of the women in the control group.The levels of the serum TGF-β1,IL-2 and MMP-9 of the women after surgery were significantly lower than those before surgery,the serum TGF-β1 level of the women was positively correlated with their serum IL-2 and MMP-9 levels,and the serum IL-2 level of the women was positively correlated with their serum MMP-9 level(all P＜0.05).ROC curve analysis showed that the area under curve(AUC),the sensitivity and the specificity of the TGF-β1 level of the women for diagnosing their infertility were 0.941,88.3％and 94.0％,respectively,which of the IL-2 level of the women for diagnosing their infertility were 0.778,66.7％and 84.0％,respectively,which of the MMP-9 level of the women for diagnosing their infertility were0.946,88.3％and 86.0％,respectively,and which of the combined levels of the serum TGF-β1,IL-2 and MMP-9 of the women for diagnosing their infertility were 0.992,93.3％and 100.0％,respectively.Logistic regression analysis showed that the abnormal increasing serum TGF-β1,IL-2 and MMP-9 levels of the women were the risk factors of the infertility caused by fallopian tube obstruction of the women(all P＜0.05).Conclusion:The levels of the serum TGF-βi,IL-2 and MMP-9 of the infertility women caused by fallopian tube obstruction are highly expressed,which are the risk factors of their infertility.The combined detec-tions of the serum TGF-β1,IL-2 and MMP-9 of the women for diagnosing their infertility has high value for their tubal obstructive infertility.
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