Value of the prenatal serum immunoglobulin G Anti A(B)antibody titer score of pregnant women with type O blood for e-valuating the occurrence of the hemolytic disease of their newborn
Objective:To explore the value of the prenatal serum immunoglobulin G(IgG)Anti A(B)antibody titer score of pregnant women with type O blood for evaluating the occurrence of the hemolytic disease of their newborn(HDN).Methods:The clinical data of 101 pregnant women with type O blood who had admitted to the hospital from January 2022 to December 2023 were selected retrospectively,and these women were divided into group A(26 women with HDN)and group B(75 women without HDN)according to the presence or absence of their HDN.The clinical data and the prenatal titer score of the serum IgG anti-A(B)antibody of the women were compared between the two groups.Spreaman correlation analysis was utilized to discuss the correlation between the prenatal titer score of the ser-um IgG anti-A(B)antibody of the pregnant women and the occurrence of their HDN.The predictive value of the pre-natal titer score of the serum IgG anti-A(B)antibody of the women with type O blood for predicting the occurrence of their HDN was evaluated by receiver operating characteristic(ROC)curve.Results:The prenatal serum IgG anti-A(B)antibody titer of the women in group A was significantly higher than that of the women in group B.When the pre-natal serum IgG anti-A(B)antibody titer of the women in the two groups was the same,the serum IgG anti-A(B)antibody titer score of the women in group A was significantly higher than that of the women in group B(all P＜0.05).Spearman correlation analysis showed that the prenatal serum IgG anti-A(B)antibody titer score of the women with type O blood was positively correlated with the occurrence of their HDN(r=0.666,P＜0.001).ROC curve analysis showed that the area under curve,the cutoff value,the sensitivity and the specificity of the prenatal serum IgG anti-A(B)antibody titer score of the women with type O blood for predicting the occurrence of their HDN were 0.874,54.88,94.7％and 84.0％,respectively.Conclusion:The prenatal serum IgG anti-A(B)antibody titer score of the women with type O blood is positive correlation with the probability of their HDN occurrence,and which has certain predictive value for the occurrence of the HDN.
Pregnant women with type O bloodSerum IgG anti-A(B)antibody titerTiter scoreHemolytic disease of newbornClinical value
NETL
NSTL
万方数据
