Correlation between the depression and anxiety of patients with the first assisted reproductive technology and their family function and stigma and its influence on the outcomes of assisted reproduction
Objective:To explore the correlation between the depression and anxiety of patients with the first assisted reproductive technology and their family function and stigma,and to study its influence on the outcomes of assisted re-production.Methods:A total of 162 patients who received assisted reproductive technology for the first time in the hospital from October 2022 to October 2023 were selected in this study.On the first day of the treatment cycle,the general data questionnaire,the self-rating depression scale(SDS),the self-rating anxiety scale(SAS),the family AP-GAR index(APGAR)and the infertility stigma scale(ISS)were used to investigate the baseline data,the situation of anxiety and depression,the family function and the stigma of these patients.The differences of the baseline data,the family function and the stigma were compared between the patients with and without depression and anxiety symp-toms.The correlation between the family function and stigma of the patients with the first assisted reproductive tech-nology and their depression and anxiety symptoms after adjusting confounding factors was analyzed by logistic regres-sion analysis model.The depression and anxiety symptoms of the patients with assisted reproduction were observed.Results:A total of 162 questionnaires were delivered,and 152 effective questionnaires were returned,and with the ef-fective rate of 93.8％.The scores of APGAR,ISS,SDS and SAS of these patients were 7.68±0.82 points,70.44±16.13 points,43.71±8.53 points and 47.94±9.05 points,respectively.The detection rates of depression and anxiety of these patients were 30.9％and 38.8％.The age,the place of residence,the education level,the duration of infertil-ity,the abortion history,the APGAR and ISS scores of the patients with the first assisted reproductive technology were correlation with their depressive symptoms.And the place of residence,the family income,the duration of infer-tility,the abortion history,the APGAR and ISS scores of the patients with the first assisted reproductive technology were correlation with their anxiety symptoms(all P＜0.05).There was a significant collinearity between the APGAR score of the patients and their ISS score.So the APGAR score and the ISS score of the patients were introduced into the multivariate logistic regression model respectively,and after adjusting the confounding factors of the depression and anxiety,the results showed that the high APGAR score of the patients was an independent protective factor of their de-pression and anxiety after assisted reproductive technology(OR=0.405,0.427),but the high ISS score was an inde-pendent risk factor of their depression and anxiety(OR=1.299,1.271).The clinical pregnancy rate of the patients with depression or anxiety(48.9％or 45.8％)was significantly lower than that(67.6％or 72.0％)of the patients without de-pression or anxiety(all P＜0.05).Conclusion:The patients with the first-time assisted reproduction are prone to de-pression and anxiety symptoms,which can adversely influence on their outcomes after assisted reproduction.The sys-tematic family and psychological intervention may be a potential way to improve the depression and anxiety symptoms of the patients.
Assisted reproductionDepression and anxietyFamily functionStigmaOutcomes of assisted reproduc-tion
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