Efficacy of Gongliuxiao capsule for treating patients with abnormal uterine bleeding
Objective:To explore the efficacy and safety of Gongliuxiao capsule for treating patients with abnormal uter-ine bleeding(AUB),and to study its influence on the levels of the hemoglobin(HGB),sex hormones and coagulation function indexes of the patients.Methods:82 patients with AUB were selected and were divided into the study group and control group(41 cases in each group)by random number table from January 2021 to September 2023.The patients in the two groups were given treatment of dydrogesterone tablet,and the patients in the study group were given Gong-liuxiao capsule additionally.The clinical efficacy and the safety of the patients after 3 months of treatment were com-pared between the two groups.The changes of the levels of HGB and sex hormones levels,the endometrial thickness and the coagulation function indexes levels of the patients in the two groups before and after treatment were monitored.Results:The total effective rate(92.7％)and the Hb level(126.93±16.53 g/L)of the patients in the study group after treatment were significantly higher than those(75.6％and 101.16±13.46 g/L)of the patients in the control group.The levels of luteinizing hormone(35.12±5.64 U/L),estradiol(185.73±11.26 U/L)and follicle stimulating hormone(24.86±4.59 U/L),and the values of activated partial thromboplastin time(24.68±1.09 s),prothrombin time(12.26±0.13 s)and thrombin time(15.03±0.27 s),the fibrinogen level(2.65±0.24 g/L)and the endometrial thickness(6.67±1.24 mm)of the patients in the study group after treatment were significantly lower than those(43.56±3.82 U/L,248.53±9.36 U/L,32.37±5.14 U/L,29.74±2.36 s,13.27±0.39 s,17.39±0.86 s,3.49±0.43 g/L and 9.37±2.01 mm)of the patients in the control group.The incidence of the adverse reactions(7.3％)of the patients in the study group was significantly lower than that(24.4％)of the patients in the control group(all P＜0.05).Conclusion:The dydrogesterone tablet combined with Gongliuxiao capsule for treating the patients with AUB can improve the efficacy,which can effectively promote the levels of the HGB and sex hormones,and the endometrial thickness recovery,and improve the coagulation function of the patients,and with the higher safety.
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