Objective:To exploration of the gene detection for the instructional aspirin precision medicine for patients with immune recurrent spontaneous abortion.Methods:50 patients with recurrent spontaneous abortion who had trea-ted in hospital between June 2022 and December 2023 were collected in this study.The genetic testing based on blood samples of these patients were conducted before their aspirin administration,and the medication regimen of aspirin was adjusted according to the genetic testing results.Results:Genetic testing was performed on 50 patients with recurrent spontaneous abortion.Three genotypes GG,GA,and A A of the aspirin resistance genes CYP2C19 and CHIA were de-tected,and three genotypes AC,CC,and AA of gene LTC4S were detected.Two genotypes CC and CT of drug effica-cy gene GP1BA were detected.All the genotypes detected of gene PTGS1 were AA.Based on the gene test results,the subsequent guidance of aspirin administration was provided to the patients.Among 50 patients with aspirin used,21 cases had changed their treatment regimens,and 3 cases had continual their treatment regimens but required close mo-nitoring of their drug adverse reactions.Conclusion:Aspirin pharmacogenomic testing for the patients with recurrent miscarriage can precisely guide their clinical drug used.
关键词
复发性流产/阿司匹林/药物相关基因/基因多态性/精准用药
Key words
Recurrent spontaneous abortion,Aspirin,Drug-related gene/Gene polymorphism/Precise medical regi-men
维普
万方数据