Effects of the different concentrations of ropivacaine used in the combined spinal epidural anesthesia during cesarean sec-tion of women with gestational iabetes mellitus on their microcirculation and oxidative stress response
Objective:To compare the effects of the different concentrations of ropivacaine used in the combined spinal epidural anesthesia during cesarean section of women with gestational iabetes mellitus(GDM)on their microcirculation and oxidative stress response.Methods:150 pregnant women with GDM who wanted cesarean section were randomly divided into three groups(50 cases in each group)from January 2022 to December 2023.The women in group A,group B and group C during the combined spinal epidural anesthesia for their cesarean section were given ropivacaine concentrations of 0.25％,0.375％,and 0.5％,respectively.And the anesthesia effect of the women was compared a-mong the three groups.Results:The onset time of the sensory block or the motor block of the women in group B and in group C were significantly shorter than those of the women in group A.At 10min after anesthesia and at the time of the fetal delivery,the mean arterial pressure values of the women in group B and in group C were significantly lower than those of the women in group A.The heart rate values of the women in group B and in group C were significantly higher than those of the women in group A.The VAS scores of the women in group B or in group C at 1,2,12 and 24h after operation were significantly lower than those of the women in group A.The length and the width of the loop of the women in group B and in group C in postoperative 24 hours were significantly higher than those of the women in group A.The malondialdehyde of the women in group A,in group B and in group C in postoperative 24 hours had de-creased gradually,but the superoxide dismutase level had increased gradually.The incidence of the adverse reactions(4.0％vs.14.0％vs.26.0％)of the women had significant difference among the three groups,and which of the women in group C was the highest(P＜0.05).Conclusion:The effect of the different concentrations of ropivacaine used in the combined spinal epidural anesthesia during cesarean section of women with GDM is different.0.375％ropi-vacaine used in the combined spinal epidural anesthesia can meet the anesthesia needs and has acceptable safety,that making it worth applying.
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