Application effect of sufentanil combined with ropivacaine used in the combined spinal-epidural block for painless labor of primiparas
Objective:To explore the application effect of sufentanil combined with ropivacaine used in the combined spinal-epidural block for painless labor of primiparas.Methods:A total of 90 primiparas who wanted painless labor were selected and were divided into two groups(45 cases in each group)by the random number table method between August 2021 and August 2023.The primiparas in the control group were given ropivacaine in the combined lumbar-epi-dural block painless labor,and the primiparas in the observation group were given sufentanil combined with ropivacaine in the combined lumbar-epidural block for painless labor.The levels of the serum prolactin(PRL),adiponectin(APN)and tissue plasminogen activator(t-PA)of the primiparas before analgesia and at 5 min after labor were compared be-tween the two groups.The analgesic indicators values and the analgesia effective time,the first time of patient-con-trolled epidural analgesia(PCEA)used,the duration of analgesia,the three stages of labor time,the delivery out-comes and the adverse reactions rate of anesthesia of the primiparas were compared between the two groups.Results:The levels of the serum PRL,APN and t-PA of the primiparas in the two groups at 5 min after delivery were signifi-cantly higher than those before analgesia,and the levels of PRL and APN of the primiparas in the observation group were significantly higher than those of the primiparas in the control group,but the t-PA level of the primiparas in the observation group was significantly lower(P＜0.05).The effective time of analgesia(5.83±1.25 min)of the primipa-ras in the observation group was significantly shorter than that(12.39±3.08 min)of the primiparas in the control group,and the time of the first time of PCEA used(86.01±9.11 min)of the primiparas in the observation group was significantly later than that(49.83±7.26 min)of the primiparas in the control group.The duration of analgesia(313.24±70.67 min)of the primiparas in the observation group was significantly longer than that(265.57±64.82 min)of the primiparas in the control group,and the duration of three stages of labor of the primiparas in the observa-tion group was significantly shorter than that of the primiparas in the control group(P＜0.05).There were no signifi-cant differences in the pregnancy outcomes and the rate of adverse reactions of anesthesia of the primiparas between the two groups(P＞0.05).Conclusion:Sufentanil combined with ropivacaine used in painless labor of the primiparas can improve their analgesia effect,and which can control the fibrinolytic function of the body and shorten the duration of labor of the primiparas.It is conducive to the smooth labor and the lactation after labor of the primiparas.Moreover,it has no significant effect on the delivery outcomes and the adverse reactions of anesthesia of the primiparas.
Painless laborPrimiparasSufentanilRopivacaineCombined lumbar-epidural blockAnalgesic effectStage of laborDelivery outcomesAdverse reaction
万方数据
维普
