Effects of flurbiprofen axetil combined with sufentanil used in patient-controlled intravenous analgesia of patients on their pain and stress factor level after endometrial cancer surgery
Objective:To explore the effects of flurbiprofen axetil combined with sufentanil used in patient-controlled intravenous analgesia(PCIA)of patients on their pain and stress factor level after endometrial cancer surgery.Meth-ods:124 patients who planned to undergo endometrial cancer surgery in the hospital were selected and were divided in-to two groups(62 cases in each group)according to the random number table method from September 2019 to June 2023.The patients in the observation group were given postoperative flurbiprofen axetil combined with sufentanil for PCIA and the patients in the control group were given postoperative sufentanil for PCIA.The score of visual analogue scale(VAS)at 2h,4h,8h,12h,24h,36h and 48h after surgery,the changes of the stress factor levels before and af-ter surgery and the occurrence of adverse reactions rate of the patients were compared between the two groups.Re-sults:The VAS scores of the patients in the two groups at 2h,4h,8h,12h,24h,36h and 48h after surgery had downward trend,and which(3.68±0.54 points,3.57±0.51 points,3.16±0.47 points,2.68±0.40 points,2.24±0.36 points,2.06±0.38 points and 1.97±0.39 points)of the patients in the observation group were significantly lower than those(4.25±0.63 points,4.09±0.56 points,3.62±0.53 points,3.19±0.45 points,2.81±0.44,2.52±0.40 points and 2.34±0.42 points)of the patients in the control group(all P＜0.05).The levels of the serum cortisol(Cor),adre-nocorticotropic hormone(ACTH),norepinephrine(NE)and neuropeptide Y(NPY)of the patients in the two groups had increased first and then decreased,and which of the patients in the observation group were significantly lower than those of the patients in the control group(all P＜0.05).The incidence of the adverse reactions(6.5％)of the patients in the observation group was significantly lower than that(14.5％)of the patients in the control group(P＞0.05).Conclusion:Flurbiprofen axetil combined with sufentanil used in PCIA of the patients with endometrial cancer surgery can reduce their postoperative pain and stress response,and with the lower adverse reaction rate.
Endometrial cancer surgeryPatient-controlled intravenous analgesiaFlurbiprofen axetilSufentanilPostoperative analgesiaStress response
万方数据
维普
