Objective To investigate the relationship between childhood abuse,emotion regulation strategies and depression symptoms in college students,and to assess the mediating role of emotion regulation strategies in the relationship between childhood abuse and depression symptoms in college students.Methods A supervised cross-sectional survey was conducted on 1172 college students using Childhood Trauma Questionnaire,Emotion Regulation Questionnaire and Self-rat-ing Depression Scale.Results Childhood abuse was positively associated with expressive suppression(r=-0.171-0.271,P<0.01)and depression symptoms(physical symptoms,emotional symptoms and body symptoms)(r=0.084-0.089,P<0.01),and negatively correlated with cognitive reappraisal(r=0.160-0.455,P<0.01).Depression symp-toms was positively associated with expressive suppression(r=-0.107--0.270,P<0.01)and negatively correlated with cognitive reappraisal(r=0.106-0.180,P<0.01).Cognitive reappraisal and expressive suppression played a media-ting role in neglect and physical symptoms and emotional symptoms,and the mediating effect accounted for 15.77%and 15.42%of the total effect.Conclusion Childhood abuse and emotion regulation strategies are closely related to depression in college students.Childhood abuse can not only directly affect the occurrence of depression,but also impact the occurrence of depression through cognitive reappraisal and expressive suppression.