Association of myopia between parental generation and their offspring aged 3 to 9 years in six provinces in China
Objective To investigate the prevalence of myopia in children aged 3 to 9 years and their parents in different birth generations,and to analyze the influence of parental myopia in different generations on the myopia of their children for providing reference for prevention and control of myopia in the future.Methods Relying on local centers for Disease Control and Prevention or education bureaus,a survey on myopia prevention and control among children aged 3-9 years and their parents was conducted in six provinces,including Liaoning Province,Jiangsu Province,Hunan Province,Anhui Province,Guangdong Province and Jiangxi Province.The Chi-square trend test was used to analyze the parents'myo-pia and medium and high myopia in different generations,and the binary ordered logistic regression model was used to ana-lyze the influence of parents'myopia degree in different generations on children's myopia.Results The overall myopia rates of fathers and mothers were 37.3％and 45.0％,respectively.The overall myopia rates of their sons and daughters aged 3-9 years were 19.0％and 20.0％,respectively.Among them,parents born between 1985 and 1989 had the highest rates of myopia,at 40.8％and 48.3％respectively.Fathers born between 1995 and 1999 had the lowest myopia rate at 26.6％,mothers born between 1970 and 1974 had the lowest myopia rate at 17.9％.Taking fathers born in different decades without myopia as the reference group,adjusted binary ordered logistic regression analysis showed that fathers who were born in 1975-1979,1980-1984,1985-1989,and 1990-1994 and had mild myopia or moderate to high myopia increased the risk of myopia in their children,the OR values were 1.55,1.62,1.35,1.46,1.30,1.74,1.41 and 1.42 respective-ly.Taking mothers who were born in different decades without myopia as the reference group,mothers who were born in 1970-1974 and had mild myopia,mothers who were born in 1975-1979 and had moderate to high myopia,and mothers who were born in 1980-1984,1985-1989,and 1990-1994 and had mild myopia or moderate to high myopia increased the risk of myopia in their children.The OR values were 9.37,1.56,1.49,1.89,1.45,1.77,1.33,1.74,1.56,and 1.67 respectively(P＜0.05).Conclusion The heritability of myopia is relatively stable,but the mechanism of environ-mental changes affecting individual myopia is different in different historical backgrounds.Therefore,parents should pay at-tention to the prevention of myopia in their young children in critical period of development in order to delay the occurrence and development of myopia through scientific intervention measures.
GenerationParental myopicMyopia in childrenDegree of severity
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