Objective To explore effective health education model for the prevention and control on key infectious diseases and improvement of the knowledge and skills of hepatitis B and AIDS prevention and control among university students.Methods Health education and work training programs were carried out in two specific universities.A volunteers team in each university implemented a two-week peer education.Electronic questionnaire was used to determine knowledge and awareness level and evaluate the effect of peer education on hepatitis B and AIDS among university students.Results After peer education,the accuracy rates of"having sex with hepatitis B carriers could infect hepatitis B"and"having sex using condoms could prevent hepatitis B"increased significantly,from 70.26%to 85.20%and 77.41%to 89.65%respectively(P<0.05).Although the accuracy rates of"mosquito bites or sharing bathtubs and swimming pools with infected persons could not infect AIDS"improved statistically significantly(P<0.05),they still remained at low level,60.99%and 66.43%respectively.After the activity,89.24%of the students were willing to actively engage in hepatitis B and AIDS pre-vention and control volunteer activities(P<0.05).Conclusion Recruiting volunteers to carry out peer education is con-ducive to the prevention and control of hepatitis B,AIDS and other infectious diseases in universities,which needs to be continuously promoted later.