Objective The global burden of chronic non-communicable diseases cannot be ignored.Compared with for-eign cohort studies,domestic studies started late,the scale is small,the implementation period of the project is short and there is no long-term stable support.Methods In 2019,West China Hospital of Sichuan University led the construction of a natural population health cohort study in western Sichuan.In the city of medical and conjoined hospital,using the convenient sampling method,the baseline health information of the permanent population aged over 20 years was collected through questionnaire sur-vey,physical examination,biological sample collection and auxiliary examination,etc.,and the new etiologies and risk factors of local major diseases and rare diseases were analyzed.The follow-up was continued for many years to observe the incidence and prevalence of target diseases in the population,as well as the high-risk factors affecting the prognosis of diseases,etc.,so as to establish a multi-dimensional,dynamic and quantitative bioinformatics big data collection system.Results Until March 2023,the West China Cohort Study has been carried out in Longquanyi District of Chengdu,Pidu District,Mianzhu City of Deyang City,Kangding City and Seda County of Garze Tibetan Autonomous Prefecture,covering 122 communities,with a total of more than 40 000 people enrolled,and a total follow-up of more than 40 000 people.Among them,24 251 people were in-cluded in Longquanyi District with a total follow-up of 3 times,10 219 people were included in Pidu district,8860 people were included in Mianzhu City of Deyang City with a total follow-up of 2 times,and 2225 people were included in Garze Tibetan Autonomous Prefecture.Conclusion By summarizing the work experience in the management of cohort study in West China Hospital,this paper explores the establishment of a large-scale natural population cohort study system with medical institutions as the main body under the background of the new era,and provides reference for other units and regions to carry out cohort studies.
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