Polyelectrolyte Multilayer Coating on 3D Printed PEGDA/TCP Scaffold with Improved Cell Proliferation

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外文摘要：Bioactive coating of ceramic scaffolds is an effective way to ameliorate osseointegration and attenuate implant-induced inflammatory responses,which should be biocompatible and possess suitable mechani-cal properties to regulate cell adhesion and migration.In this study,a poly(ethylene glycol)diacry-late/tricalcium phosphate(PEGDA/TCP)ceramic scaffold was prepared using SLA-3D printing,and its com-pressive strength was 8.9±1.0 MPa.Chitosan(Chi)and chondroitin sulfate(CS)were assembled on the sur-face of the PEGDA/TCP scaffolds and crosslinked with 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide/N-hydroxysuccinimide(EDC/NHS).Scanning electron microscope(SEM),Fourier transform infrared(FTIR),and laser scanning microscope were used to evaluate the surface modification of the PEGDA/TCP scaffolds.Cellu-lar tests showed that polyelectrolyte multilayers(PEMs)promoted cell adhesion and proliferation of osteoblasts relative to unmodified scaffolds.Furthermore,it can be demonstrated that the SLA-3D printed TCP scaffolds could meet the compressive requirements of trabecular bones,and the bioactivity of the bone scaffolds could be effectively improved by combining them with Chi/CS PEM.

外文关键词：

3D printingTricalcium phosphatePolyelectrolyte multilayerCell proliferation

作者：

Xingguo Zhou、Bin Zou、Qinghua Chen、Qingguo Lai、Tao Quan、Xianhua Ma、Gongxian Yang

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作者单位：

Center for Advanced Jet Engineering Technologies(CaJET),School of Mechanical Engineering,Shandong University,Jinan,250061,China

Key Laboratory of High Efficiency and Clean Mechanical Manufacture,Ministry of Education,Shandong University,Jinan,250061,China

National Demonstration Center for Experimental Mechanical Engineering Education(Shandong University),Jinan,250061,China

Research Center of Rapid Manufacturing,Additive Manufacturing Research Center of Shandong University of National Engineering,Jinan,25006

Department of Oral and Maxillofacial Surgery,The Second Hospital,Cheeloo College of Medicine,Shandong University,Jinan,250033,China

Research Center of 3D Printing in Stomatology of Shandong University,Jinan,250033,China

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基金：

National Key Research and Development Project of ChinaNational Natural Science Foundation of China

项目编号：

2022YFB460140352175336

出版年：

2024

DOI：

10.1016/j.amf.2024.200114

中国机械工程学报:增材制造前沿(英文)

ISSN：

年,卷(期)：2024.3(1)