首页|The Effects of Structural & Materials Design on the Mechanisms of Tissue Integration with the 3D Printed Polyether-Ether-Ketone Cranial Implants in Vivo

The Effects of Structural & Materials Design on the Mechanisms of Tissue Integration with the 3D Printed Polyether-Ether-Ketone Cranial Implants in Vivo

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
3D printed polyether-ether-ketone(PEEK)implant has become a popular clinical alternative to implants made of titanium alloy for cranial bone substitutes due to its bone-match properties,however its biological inert hin-dered the progress of clinical applications of such material.To enhance the tissue integration capability of PEEK implants and promote their long-term stability,cranial implants of gradient porous structures were designed and manufactured via fused filament fabrication(FFF)3D printing technology in both PEEK and PEEK/HA com-posites materials,then functionally evaluation of the implants on the tissue in-growth and the osteointegration mechanisms was conducted via animal tests.The 3D printed PEEK scaffold was found to have 2-5 folds of the compressive strength to those of the natural cranial bone.The in vivo studies verified that the porous PEEK/HA scaffold could effectively induce the bone ingrowth to form a stable biointegration boundary surrounding the host bone tissue after 4 weeks of implantation.Moreover,the PEEK/HA scaffold showed no significant advantages in improving the soft tissue in-growth,only making its distribution more evenly.It is also interestingly to find out that the vertically connective pores throughout the implant did not enhance the tissue binding force even though it did promote the nutrient transportation.In conclusion,the use of PEEK/HA composite material and a well-designed porous structure was proved to be an effective approach to improve the biointegration between the implant and host tissues.

FFF 3D printingPEEK/HA compositeGradient porous scaffoldCranial implantBiointegration

Ling Wang、Ziyu Wang、Jiayin Liu、Yijun Hui、Yanwen Su、Chenrui Zhang、Changning Sun、Kaishu Li、Dichen Li、Yawei Liu

展开 >

State Key Laboratory for Manufacturing System Engineering,Xi'an Jiaotong University,Xi'an,710054,China

School of Mechanical Engineering,Xi'an Jiaotong University,Xi'an,710054,China

NMPA Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices,Xi'an,710054,China

Department of Neurosurgery & Medical Research Center,Shunde Hospital,Southern Medical University(The First People's Hospital of Shunde Foshan),Foshan,528300,China

Cell Therapy Center,Beijing Institute of Geriatrics,Xuanwu Hospital Capital Medical University,National Clinical Research Center for Geriatric Diseases,Key Laboratory of Neurodegenerative Diseases,Ministry of Education,Beijing,100053,China

Department of Neurosurgery,The Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People's Hospital,Qingyuan,511518,China

展开 >

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNatural Science Basic Research Program of Shaanxi Province of ChinaFundamental Research Funds for the Central UniversitiesProgram for Innovation Team of Shaanxi Province of ChinaNatural Science Foundation of Guangdong Province of China

51835010122023472022JQ-3782023-CX-TD-172022A1515012552

2024

10.1016/j.amf.2024.200112

中国机械工程学报:增材制造前沿(英文)

中国机械工程学报:增材制造前沿(英文)

ISSN：
年,卷(期)：2024.3(1)