Durotaxis and Topotaxis Orchestrated Guidance on Cell Migration in 3D Printed Scaffold/Hydrogel Composite

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外文摘要：Printing three-dimensional(3D)scaffolds with suitable mechanical cues is an effective strategy for guiding tissue regeneration by inducing cell migration and growth.Nevertheless,many studies considered only one type of cue for 3D tissue engineering scaffold fabrication,such as topological cues,which is insufficient.To realize durotaxis-and topotaxis-orchestrated guidance on cell migration,a 3D printed scaffold/hydrogel composite was fabricated in this study.The porous scaffold provided a topological cue(topotaxis),and the combined hydrogel provided a compliance cue(durotaxis).The results indicated that the thin fibers of the scaffold induced cell migration,and the larger pore size and directed fiber number of the scaffold led to more uniform cell orientation(topotaxis).Furthermore,when collagen was cured to cover the scaffold to result in a compliance change,the cells in the collagen still sensed the scaffold topological cue and migrated along it(durotaxis).Collagen also provides a living space and nutrition for cells,thereby significantly increasing their number.The effects of durotaxis and topotaxis synthesis provide a promising solution for tissue engineering scaffold applications.

外文关键词：

Tissue engineering scaffoldTopological cueCompliance cueCell migration

作者：

Baichuan Deng、Zhiwei Huang、Xianglin Zhang、Kai Ren、Wen Feng Lu、Jerry Ying Hsi Fuh、Xinghuang Liu、Tao Bai、Bin Wu

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作者单位：

State Key Laboratory of Materials Processing and Die & Mould Technology,School of Materials Science and Engineering,Huazhong University of Science and Technology,Wuhan,430074,China

State Key Laboratory of Fluid Power and Mechatronic Systems,School of Mechanical Engineering,Zhejiang University,Hangzhou,310027,China

Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province,School of Mechanical Engineering,Zhejiang University,Hangzhou,310027,China

Department of Mechanical Engineering,National University of Singapore,Singapore,117575,Singapore

Division of Gastroenterology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China

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基金：

National Natural Science Foundation of ChinaHubei Provincial Natural Science Foundation of ChinaHubei Provincial Natural Science Foundation of ChinaKey Research and Development Plan of Zhejiang ProvinceEzhou Industrial Technology Research Institute,Huazhong University of Science and TechnologyState Key Laboratory of Materials Processing and Die & Mould Technology of Huazhong University of Science and TechnologyHuazhong University of Science and Technology Analytical & Testing Center for various characterizations

项目编号：

523055582023AFB1412023AFB8072023C01169

出版年：

2024

DOI：

10.1016/j.amf.2024.200134

中国机械工程学报:增材制造前沿(英文)

ISSN：

年,卷(期)：2024.3(2)