建设基于下一代测序技术(NGS)的传染病监测预警平台构想
The Establishment of an Early Warning Platform for Infectious Disease Surveillance Based on Next-Generation Sequencing Technology
潘衍宇 1竺文杰 1金东新 2刘曦宇 2张俊波1
作者信息
- 1. 镇海海关 宁波 315000
- 2. 宁波海关 宁波 315000
- 折叠
摘要
我国海关坚持"口岸疫情防控海关必坚守"要求,身处"外防输入"的第一线,严格落实"多病同防"工作,亟需既能进行深度病原识别及精准溯源,又能承担未来口岸常规传染病监测的统一化实验室监测预警平台.下一代测序技术为口岸在传染病监测提供了新的借鉴思路.本文介绍了若干全球范围内传统及新型的传染病监测预警平台架构及优缺点,并提出了组建基于下一代测序技术的海关系统新型传染病监测预警实验室平台的一些设计构想,为科学精准做好口岸疫情防控工作,实现精准检疫提供技术性参考.
Abstract
In recent years,serving as the front-line defense against imported cases,China Customs adheres to the requirement of"the Customs must stand firm in preventing and controlling epidemics at ports",and strictly implement the task of"multi-disease prevention".There is an urgent need for a unified laboratory monitoring and early warning platform that can not only conduct in-depth pathogen identification and precise tracing,but also undertake routine monitoring of infectious diseases at ports in the future.The rise and application of Next Generation Sequencing(NGS)technology in the field of early warning provides a new perspective for infectious disease surveillance at customs ports.This article introduces the architecture,advantages and disadvantages of traditional and new infectious disease monitoring and early warning platforms around the world,and puts forward some design thoughts for the establishment of a new platform within the customs system based on NGS,aiming to provide reference for accurate prevention and control of epidemics at ports and realize precise quarantine.
关键词
全基因组测序/宏基因组测序/传染病监测预警/海关Key words
whole genome sequencing/metagenomic Next-Generation Sequencing(mNGS)/monitoring and early warning of infectious diseases/customs引用本文复制引用
基金项目
国家重点研发计划(2021YFC2301105)
出版年
2024
NETL
NSTL
万方数据