首页|宿迁市256名艾滋病患者基线病毒载量及淋巴细胞亚群的分析

宿迁市256名艾滋病患者基线病毒载量及淋巴细胞亚群的分析

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本文回顾性分析 2019 年 1 月至 2023 年 10 月宿迁市 256 名艾滋病(Acquired Immunodeficiency Syndrome,AIDS)患者的基线病毒载量水平及淋巴细胞亚群水平,为科学防控艾滋病提供理论依据.通过收集256 例艾滋病患者的临床资料、实验室检查结果,总结其基线病毒载量及淋巴细胞亚群的特征,对数据进行相关性分析.结果显示,艾滋病病毒载量水平在性别上存在差异(P<0.05),基线CD4+T细胞计数、CD4+T/CD8+T比值在年龄、确诊至抗逆转录病毒治疗(Antiretroviral Therapy,ART)的时间存在统计学差异(P<0.05),病毒载量水平与CD4+T细胞计数、CD4+T/CD8+T比值总体呈显著负相关(P<0.05),CD4+T细胞计数与CD4+T/CD8+T比值呈显著正相关性,与年龄、确诊至ART时间、病毒载量呈负相关.结果表明宿迁市艾滋病患者中高病毒载量人数较多,以小于50岁青壮年为主.病毒载量高可能是造成CD4+T细胞计数、CD4+T/CD8+T比值低下的重要因素,应进一步加大检测人群的比例,早发现,早治疗,以便提高艾滋病患者的抗病毒疗效,改善预后.
Analysis of Baseline Viral Load and Lymphocyte Subsets of 256 AIDS Patients in Suqian City
The baseline viral load and lymphocyte subsets of 256 Acquired Immunodeficiency Syndrome(AIDS)patients in Suqian City from January 2019 to October 2023 were retrospectively analyzed to provide a theoretical basis for scientific prevention and control of AIDS.The clinical data and laboratory results of 256 AIDS patients were collected.The characteristics of baseline viral load and lymphocyte subsets were summarized,and the correlation analysis was carried out.The results showed that HIV-RNA levels were different in gender(P<0.05),and baseline CD4+ cell count and CD4+/CD8+ ratio were significantly different in age and time from diagnosis to Antiretroviral Therapy(ART)(P<0.05).Viral load was negatively correlated with CD4+ count and CD4+/CD8+ ratio(P<0.05),and positively correlated with CD4+ count and CD4+/CD8+ ratio(P<0.05).The results showed that there were a large number of HIV patients with high viral load in Suqian City,mainly young adults under the age of 50.High viral load may be an important factor for low CD4+ count and CD4+/CD8+ ratio.The proportion of the testing population should be further increased,and early detection and early treatment should be carried out to improve the antiviral efficacy and prognosis of AIDS patients.

Acquired Immunodeficiency Syndrome(AIDS)viral loadlymphocyte subsetsCD4+/CD8+ ratio

姬会春、张振江、杨国平、苏小建、鲍银叶、唐辅君、吴金芳、杨庆贵

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南京医科大学附属宿迁第一人民院 宿迁 223800

江苏国际旅行卫生保健中心(南京海关口岸门诊部) 南京 210019

宿迁海关 宿迁 223800

宿迁市宿城区疾病预防控制中心 宿迁 223800

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艾滋病(AIDS) 病毒载量 淋巴细胞亚群 CD4+T/CD8+T比值

中国公共卫生联盟课题

GWLM202017

2024

中国口岸科学技术
中国质检报刊社

中国口岸科学技术

影响因子:0.051
ISSN:1002-4689
年,卷(期):2024.6(3)
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