首页|Higher levels of the lipophilic antioxidants coenzyme Q10 and vitamin E in long-lived termite queens than in short-lived workers
Higher levels of the lipophilic antioxidants coenzyme Q10 and vitamin E in long-lived termite queens than in short-lived workers
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Termite queens and kings live longer than nonreproductive workers.Several molecular mechanisms contributing to their long lifespan have been investigated;however,the underlying biochemical explanation remains unclear.Coenzyme Q(CoQ),a compo-nent of the mitochondrial electron transport chain,plays an essential role in the lipophilic antioxidant defense system.Its beneficial effects on health and longevity have been well studied in several organisms.Herein,we demonstrated that long-lived termite queens have significantly higher levels of the lipophilic antioxidant CoQ10 than workers.Liquid chro-matography analysis revealed that the levels of the reduced form of CoQ10 were 4 fold higher in the queen's body than in the worker's body.In addition,queens showed 7 fold higher levels of vitamin E,which plays a role in antilipid peroxidation along with CoQ,than workers.Furthermore,the oral administration of CoQ10 to termites increased the CoQ10 redox state in the body and their survival rate under oxidative stress.These find-ings suggest that CoQ10 acts as an efficient lipophilic antioxidant along with vitamin E in long-lived termite queens.This study provides essential biochemical and evolutionary in-sights into the relationship between CoQ10 concentrations and termite lifespan extension.
antioxidant defense systemcoenzyme Qtermite queensvitamin E
Eisuke Tasaki、Yorihiro Yamamoto、Yoshihito Iuchi
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Department of Biological Chemistry,Graduate School of Sciences and Technology for Innovation,Yamaguchi University,Yamaguchi,Japan
Department of Biology, Fac-ulty of Science, Niigata University, 8050 Ikarashi 2-no-cho, Nishi-ku, Niigata 950-2181, Japan
School of Bioscience and Biotechnology,Tokyo University of Technology,Hachioji,Tokyo,Japan
Japan Society for the Promotion of Science(JSPS)KAKENHIJapan Society for the Promotion of Science(JSPS)KAKENHI
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