Effects of nicergoline combined with low frequency electrical stimulation therapy on dysphagia after stroke and serum neurological function indicators
Objective:To observe the effects of nicergoline combined with low frequency electrical stimulation ther-apy on patients with dysphagia after stroke and serum neurological function indicators.Methods:A total of 90 pa-tients with dysphagia after stroke who visited the Second Affiliated Hospital of Hebei North University from Sep-tember 2022 to June 2023 were randomly separated into three groups,with 30 patients in each group:group Ⅰ given routine treatment;group Ⅱ given conventional treatment combined with nicergoline;and group Ⅲ given convention-al treatment combined with nicergoline and low frequency electrical stimulation therapy.The efficacy after treatment for 2 weeks,changes in National Institutes of Health Stroke Scale(NIHSS)and Standard Swallowing Function Scale(SSA)scores,Kubota water swallow test level,serum brain derived neurotrophic factor(BDNF),nerve growth factor(NGF),and neuron specific enolase(NSE)levels before and after treatment,and the occurrence of untoward reactions of the three groups were compared.Results:The total effective rate of treatment in group Ⅲ was obviously higher than that in group Ⅰ and group Ⅱ(P＜0.05).Compared with those before treatment,the NIHSS score,SSA score,Kubota water swallow test level,and serum NSE expression level of patients in the three groups were obviously reduced after 2 weeks of treatment,those in groups B and C were better than group A(P＜0.05),and those in group C were better than group B(P＜0.05).while the expression levels of BDNF and NGF were obvi-ously increased(P＜0.05).After 2 weeks of treatment,the NIHSS score,SSA score,Wada drinking water level,and serum NSE expression level in group Ⅲ were obviously lower than those in group Ⅰ and group Ⅱ,while the ex-pression levels of BDNF and NGF were obviously higher than those in group Ⅰ and group Ⅱ(P＜0.05).There was no obvious difference in the incidence of untoward reactions among the three groups during treatment.Conclusion:The combination of nicergoline and low frequency electrical stimulation therapy can effectively treat patients with dysphagia after stroke,increase serum BDNF and NGF levels,reduce NSE level,assist patients in restoring swallo-wing function,and have good safety.
dysphagia after strokenicergolinelow frequency electrical stimulation therapyneurological func-tion
国家科技期刊平台
NSTL
万方数据
维普
