Clinical efficacy of electroacupuncture combined with repeated transcranial magnetic stimulation in the treatment of threatened migraine with different treatment sequences
Objective:To compare the therapeutic effects of electroacupuncture combined with repeated transcranial magnetic stimulation in the treatment of migraine with aura in different treatment sequences.Methods:A total of 96 migraine patients who visited the Department of Rehabilitation Medicine of our hospital from August 2022 to Sep-tember 2023 were selected as the research subjects.They were randomly divided into 3 groups using a random num-ber table method:the electric magnetic group,the magnetic electric group,and the synchronous group.All 3 groups received routine treatment,with the electroacupuncture group receiving electroacupuncture treatment first and the magnetic group receiving rTMS treatment after a 10 min interval;The group treated with rTMS first,fol-lowed by electroacupuncture after a 10 min interval;The synchronous group received rTMS and electroacupuncture treatment simultaneously,and all 3 groups were treated for 4 weeks.The patients in all groups were evaluated for pain severity using visual analog scale(VAS)before treatment,1 week,2 weeks,and 4 weeks after treatment.The migraine specific quality of life questionnaire(MSQ)was evaluated before and after 4 weeks of treatment.The sub-stance P(SP)and serotonin(5-HT)levels were detected.The transcranial Doppler ultrasound was used to detect the average blood flow velocity of the bilateral anterior cerebral artery,posterior cerebral artery,and middle cerebral artery in 3 groups.Results:There was an interaction between treatment method and time in VAS(P＜0.05),and the VAS scores in the synchronous group were significantly lower than those in the rest two groups at 2nd and 4th week of treatment(P＜0.05).After 4 weeks of treat-ment,the synchronous group had lower SP and higher 5-HT level than the rest;lower MSQ than the magnetic electric group(P＜0.05),and no significant difference from the electric magnetic group.After 4 weeks of treatment,the flow velocity of the anterior cerebral ar-tery,posterior cerebral artery,and middle cerebral ar-tery in the synchronous group was significantly lower than the rest two groups(P＜0.05).Conclusion:In clinical studies of electroacupuncture combined with repeated transcranial magnetic stimulation in the treatment of migraine with aura in different treatment sequences,synchronous treatment has the best effect,followed by the electric mag-netic scheme,and finally the magnetic electric scheme.
repetitive transcranial magnetic stimulationelectroacupuncturemigraine
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