Efficacy of tDCS in different cranial parts of the brain in the treatment of frozen gait in Parkinson's disease
Objective:To observe the clinical effect of transcranial direct current stimulation(tDCS)on frozen gait in Parkinson's disease(PD).Methods:From January 2023 to June 2023,a total of 72 PD patients hospitalized in the First Affiliated Hospital of Xinxiang Medical University were selected and divided into control group,M1 group and L-DLPFC group by a random number table method,with 24 cases in each group.In the M1 placed group,the anode was on the M1 scalp of the dominant hemisphere.In the L-DLPFC group,the anode was placed on the DLPFC scalp of the dominant hemisphere.The cathodes were placed in the contralateral supraorbital fissure.The stimulation in-tensity of M1 group and L-DLPFC group was 2 mA for 20 min every time.The position of the electrodes in control group was the same as that in M1 group,and the stimulation was given only 2 mA for 1 min.The stimulation was given for 5 consecutive days.Three scales such as MDS-UPDRS,FOG Score and TUGT were used to evaluate the effects of treatment on day 0 and day 5.Results:MDS-UPDRS 111,FOG score and TUGT time after treatment in M1 group and L-DLPFC group were significantly reduced as compared with those before treatment(P＜0.05).Com-pared with control group,MDS-UPDRS Ⅲ and FOG scores and TUGT time in M1 group and L-DLPFC group were significantly decreased after the treatment(P＜0.05).There was no statistically significant difference in the MDS-UPDRS Ⅲ and FOG scores and TUGT time between the M1 group and L-DLPFC group at the same time points.Conclusion:The tDCS in dominant hemispheres(M1 and L-DLPFC)can improve the frozen gait of patients with PD in a short time and improve the quality of life.
Parkinson's diseasefrozen gaittranscranial direct current stimulationprimary motor cortexleft dorsolateral prefrontal cortex
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